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《Journal of Norman Bethune University of Medical Science》 2003-01
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Expression of Vascular Endothelial Growth Factor during Retinopathy of Diabetic Rats

SONG E 1,XU Qi 2,WANG Xin rui 3,Wu Jia xiang 3 (1. Dept.of Ophthalmology, First Hospital, JiLin University, Changchun 130021,China; 2. Dept. of Pathophysiology,School of Basic Medical Sciencses, Jilin University; 3. Dept. of Pathomorphology, School of Basic Medical Sciencses, Jilin University)  
Objective:In order to understand the role of VEGF in diabetic retinopathy and go further into the mechanism, the expression of the VEGF during the angiogenesis in the formation of the diabetic retinopathy was examined in the study.Methods:Use STZ to get diabetic rat models, used immunohistochemistry and in situ hybridization to test the expression of VEGFmRNA and VEGF protein in retinal paraffin slide during different periods of DR. Results:①In control group (M), recovered blood sugar group and 1 month diabetic group (M 1), the morphology of retinal paraffin slides were normal and there was not expression of VEGF protein and mRNA. ②In 2 months diabetic group (M 3),there was no expression of VEGF mRNA. But VEGF protein (34%) mainly expressed in inner nuclear layer and ganglion cell layer, where GFAP expressed also. ③In 5 months diatetic group (M 5), the expression rate of VEGF mRNA was 67%. Its expression appeared in every layer of retina, and the expression of VEGF mRNA in inner limiting membrane was similar to expression of GFAP. There was eighty nine percent of sample showed strong positive expression of VEGF protein in M 5 group. The expression mainly located in cells of inner nuclear layer, ganglionic layer and vessel, which was also similar to the expression of GFAP. Conclusion:There is expression of VEGF during the development of DR in STZ rats and the expression in retina are produced by autocrine and paracrine.
【Fund】: 吉林省科委基金资助课题 (吉科会字第 990 5 75 - 5号 )
【CateGory Index】: R774.1
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