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《Journal of Jilin University of (Medicine Edition)》 2003-03
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Effect of Rg1 on learning-memory behavior and immune function in mice treated with D-galactose

QIAO Ping, YANG Gui zhen (Dept.of Immunology, School of Basic Medical Sciences, Jilin University, Changchun 130021,China)  
Objective: To investigate the role of P. pseudo ginsengvar.notoginseng Rg1 on the learning memory and immune function in D galactose induced mouse aging model. Methods:Balb/c mice were randomly divided into four groups,including D glactouse model group ,normal control group , experiment group I and experiment group Ⅱ. Stepdown and Y maze were performed to evaluate their learning and memory function , 3H thymidine incorporation( 3H TdR) were employed to determine the potency of thymus and spleen lymphocyte proliferation. The level of IL 2 and TNF α were measured by bioassay method. Results: Compared with the D galactose induced mouse model, Rg1 could improve significantly the ability of escaping electrical stimulation, increase thymus and spleen lymphocyte proliferation, alleviate the change of IL 2 and TNF α level. Conclusion:The results suggested that Rg1 may be beneficial in improving the aging process and regulating of immune function.
【CateGory Index】: R285.5
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