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《Journal of Jilin University of (Medicine Edition)》 2003-06
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Change of HBV DNA Level in the Sera of Patients with Chronic Viral Hepatic Disease and its Clinical Significance

JIN Zhen jing 1, CHI Bao rong 2 (1. Dept.of Digestive Medicine, The Second Hospital, Jilin University, Changchun 130041, China;2. Dept.of Digestive Medicine, The First Hospital, Jilin University)  
Objective: To observe the change of HBV DNA level in the sera of patients with chronic viral hepatic disease and its clinical significance. Methods:The amount of HBV DNA in the sera of patients with chronic hepatitis B (CHB), chronic severe hepatitis B (CSHB) and hepatic B cirrhosis (HBC) were measured with FQ PCR. Results: The level of HBV DNA in CSHB group was significantly lower than those in CHB and HBC groups ( P 0.01). The bilirubin level in the sera of patients with chronic viral hepatic disease of different clinical types had a inverse relationship with the level of HBV DNA. Conclusion: The patients with chronic viral hepatic disease had an unbalance on the regulation and control of immunologic function. The level of HBV DNA as well as the bilirubin level in the sera of patients can reflect the necrosis degree of liver cells.
【Fund】: 吉林省计经委资助课题 (2 0 0 0 - 9)
【CateGory Index】: R512.6
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