Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Jilin University of (Medicine Edition)》 2004-01
Add to Favorite Get Latest Update

Effects of Acanthopanax senticosus saponins on blood lipid metabolism and antioxidative activity in experimental hyperlipidemia rats

SUI Da yuan *, HAN Cong cheng,YU Xiao feng,QU Shao chun (Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 130021, China)  
Objective\ To observe the effect of Acanthopanax senticosus saponins (ASS) on total cholesterol (TC), lipoprotein cholesterol metabolism and antioxidative activity in experimental hyperlipidemia rats. Methods The TC, lipoprotein cholesterol and lipid peroxidation (LPO) contents, prostacycline (PGI 2) and thromboxane (TXA 2) levels, superoxide dismutase (SOD) activity and blood viscosity were measured respectively in hyperlipidemia rats which had been given ASS 25, 50 and 100 mg·kg -1 ·d -1 ip, respectively, for twenty one days. In addition, fat accumulation in liver was observed. Results The triglyceride (TG), TC, low density lipoprotein cholesterol (LDL c) in serum, TXA 2 in plasma, LPO in serum and liver and blood viscosity were decreased significantly, and high density lipoprotein cholesterol (HDL c) in serum, PGI 2 in plasma and SOD in serum and liver were significantly increased by given ASS (50 and 100 mg·kg -1 ·d -1 ) in experimental hyperlipidemia rats. Moreover, ASS could decrease ratioes of TC/HDL c, LDL c/HDL c, increase the ratio of PGI 2/TXA 2 and inhibit fat accumulation in liver. Conclusion ASS can inhibit arteriosclerosis by improving cholesterol and lipoprotein cholesterol metabolism, suppressing LPO,and increasing the activity of antioxidase.
【Fund】: 吉林省科技厅重点课题 (吉科合字 1 9890 31 0 - 0 5 ) ;; 吉林省中医管理局科研基金重点课题 (合同号 98A1 7)
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 SUI Da-yuan 1, YU Xiao-feng1,QU Shao-chun1, ZHAO Xue-zhong2 (1. Department of Pharmacology, School of Pharmacy, Jilin University,Changchun 130021,China; 2. Department of Cardiovascular Medicine, First Hospital, Jilin University, Changchun 130021,China);Effects of Acanthopanax senticosus saponins on myocardial ischemia-reperfusion arrhythmia in rats[J];Journal of Jilin University of (Medicine Edition);2004-04
2 ZHAO Yan-wei 1,2 , YU Xiao-feng 1, XU Hua-li 1,QU Shao-chun 1, SUI Da-yuan 1 (1. Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 130021, China; 2. Department of Pharmacology, Tianjin Medical College of Chinese People′s Armed Police Force, Tianjin 300162,China);Effects of IGFS on blood lipid metabolism in experimental hyperlipidemia rats[J];Journal of Jilin University of (Medicine Edition);2005-03
3 ZHANG Shan-yu~1, JIN Zai-jiu~1, SHEN Ying-ai~1, ZHANG Hai-yu~2(1. Research Center of Medicine and Pharmacy, Medical College, Yanbian University,Yanji 133000, China; 2. Department of Pediatric Surgery, First Hospital, Jilin University, Changchun 130021, China);Effects of Qiyue hypolipidemic tablets on blood lipid metabolism in hyperlipidemia rats[J];Journal of Jilin University of (Medicine Edition);2005-04
4 ;Curative effects of compound Chinese medicine on treatment of fatty liver with hyperlipidemia[J];Journal of Jilin University of (Medicine Edition);2005-04
5 LIU Leng1,2,XU Hua-li1,YU Xiao-feng1,QU Shao-chun1,LIANG Qi-ming1,SUI Da-yuan1(1.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China;2. Institute for Microorganism control,Center of Disease Control and Preventionin,Guangdong Province,Guangzhou 510300,China);Protective effects of Kudiezi Oral Solution on experimental hyperlipoproteinemia in rats[J];Journal of Jilin University(Medicine Edition);2008-05
6 ;Effect of Acanthopanax senticosus extract on hemorheology[J];The Chinese Journal of Clinical Pharmacology;2006-02
7 QIN Yu (Department of Biology, Tonghua Teachers′ College, Tonghua 134002, China);Effect of Polemonium laxiflorum Elikation on Experimental Hyperlipidemia Animals[J];Journal of Jilin Agricultural University;2005-03
8 LIU Wei,CHENG Lijing,WEN Xiaoxu,SUN Ling,GAO Shan,FENG Duanhao(Dept.of Pharmacy,the Second Hospital Affiliated to PLA General Hospital,Beijing 100091,China);Comparative Studies on Extracts from Radix Puerariae and Radix Acanthopanacis Senticosi in Influencing Mice Blood Rheology[J];Journal of Guangzhou University of Traditional Chinese Medicine;2007-02
9 WEN Xiao-xu,CHENG Li-jing,LIU Wei,FENG Duan-hao,SUN Ling.Second Affiliated Hospital,PLA General Hospital,Beijing 100091,China;Effect of Acanthopanax senticosus extract on erythrocyte membrane fluidity in mice[J];Shanxi Medical Journal;2006-04
10 SONG Li-zhong,HUA Jian,XU Shan-chu,et al.Department of Pharmacy,the First Affiliated Hospital of Bengbu Medical College,Anhui 233004,China;Effects of Injection Acanthopanax Senticosus on the Auricles Microcirculation in Mice with Acute Blood Stasis[J];Chinese Journal of General Practice;2009-05
China Proceedings of conference Full-text Database 1 Hits
1 Zeng Baoping (2001 pharmaceutics project of GuangZhou University of TCM) faculty adviser:Cui Jingchao Zhou Ruiling Chen Yuxing Zeng Xiaohui company:GuangDong Province Institute of TCM;Experimental study on the antihyperlipidemia effect of Fufang Jiangzhisu[A];[C];2005
【Citations】
Chinese Journal Full-text Database 3 Hits
1 LI Yan yan 1,YIN Yi zi 1,SUI Da yuan 2,YU Xiao feng 2,QU Shao chun 2,JIANG Yi 3 (1. Dept. of Medication, The First Hosprital, Jilin University, Changchun 130021,China; 2. Dept. Of Pharmacology, Pharmacy College, Jilin University; 3. Dept.;The effect of DMLI on blood lipid metabolism in hyperlipidemia rats[J];Journal of Norman Bethune University of Medical Science;2002-04
2 MA Li-na;LU Zhong-zhi; LU Wen-wei;SUI Da-yuan;CHENG Hui-zhen(Department of Pharmacolo-gy,Bethune University of Medical Sciences,Changchun 130021);Effects of Acanthopanax senticosus saponin on hemodynamics and car-dial oxygen metabolism in acute myocardial infarction in dogs[J];CHINESE PHARMACEUTICAL JOURNAL;1994-11
3 ZHANG Yu hua 1,HAN Cong cheng 2,QU Shao chun 2,YU Xiao feng 2,SUI Da yuan 2 (1? Department of Pharmacy,The Third Hospital of Jilin University,Changchun 130031, China ;2? Department of Pharmacology,Pharmacy School of Jilin University,Changchun 130021, China );Protective effect of Acanthopanax senticosus saponins on experimental myocardial infarction in rats[J];Chinese New Drugs Journal;2002-09
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 CHEN Chao et al (Department of Veterinary Medicine,College of Animal Science,Guizhou University,Guiyang,Guizhou 550025 );Effects of Perilla Seed on Blood Lipid Regulation and Lipid Peroxidation of Coturnix coturnix with Hyperlipidemia[J];Journal of Anhui Agricultural Sciences;2008-21
2 MA Rui,XU Huan,YANG Li-li,CHENG Liang,TANG Yun-guo,YE Yun(Grade 2001,Faculty of Medicine,Bengbu Medical College,Bengbu 233030,China);Protective effect of acanthopanax senticosus injection on the acute myocardial anoxia in mice[J];Journal of Bengbu Medical College;2006-01
3 LI Yan yan 1,YIN Yi zi 1,SUI Da yuan 2,YU Xiao feng 2,QU Shao chun 2,JIANG Yi 3 (1. Dept. of Medication, The First Hosprital, Jilin University, Changchun 130021,China; 2. Dept. Of Pharmacology, Pharmacy College, Jilin University; 3. Dept.;The effect of DMLI on blood lipid metabolism in hyperlipidemia rats[J];Journal of Norman Bethune University of Medical Science;2002-04
4 SUN Zhi hui 1,SHAN Gui li 1,LI Yan yan 1,SUI Da yuan 2 ,YU Xiao feng 2,QU Shao chun 2 (1. Department of Medication, First Hospital, Jilin University, Changchun 130021 ,China; 2. Department of Pharmacology, School of Pharmacy, Jilin University,Changchun 130021,China);Effects of Diemailing injection on organ blood flow and vascular resistance in anesthetized dogs[J];Journal of Jilin University of (Medicine Edition);2004-01
5 SUI Da-yuan 1, YU Xiao-feng1,QU Shao-chun1, ZHAO Xue-zhong2 (1. Department of Pharmacology, School of Pharmacy, Jilin University,Changchun 130021,China; 2. Department of Cardiovascular Medicine, First Hospital, Jilin University, Changchun 130021,China);Effects of Acanthopanax senticosus saponins on myocardial ischemia-reperfusion arrhythmia in rats[J];Journal of Jilin University of (Medicine Edition);2004-04
6 XIE Xiang-lin 1, ZHOU Ming 2, LIU Hong-yan 1 (1.Department of Pharmacology, School of Pharmacy ,Jilin University, Changchun 130021,China;2.Department of Clinical Pharmacological Laboratory ,Affiliated Hospital, Changchun College of Traditional Chinese Medicine ,Changchun 130021,China);Effects of KuDieZi oral liquid on study and memory functions in mice and rats[J];Journal of Jilin University of (Medicine Edition);2004-05
7 ZHAO Yan-wei 1,2 , YU Xiao-feng 1, XU Hua-li 1,QU Shao-chun 1, SUI Da-yuan 1 (1. Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 130021, China; 2. Department of Pharmacology, Tianjin Medical College of Chinese People′s Armed Police Force, Tianjin 300162,China);Effects of IGFS on blood lipid metabolism in experimental hyperlipidemia rats[J];Journal of Jilin University of (Medicine Edition);2005-03
8 WANG Tian, XU Hua-li , QU Shao-chun, YU Xiao-feng, SUI Da-yuan ( Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 130021, China; Department of Pharmacology, School of Pharmacy, Yantai University, Yantai 264005, China);Protective effects of Diemailing Injection on myocardial ischemia-reperfusion injury in rats[J];Journal of Jilin University(Medicine Edition);2006-01
9 ZHANG Yan,DU Bo,DU Bao-dong~(Department of Otorhinolaryngology and Head-Neck Surgery,First Hospital,Jilin University,Changchun 130021,China);Effect of Ixeris sonchifoila on inner ear function of guinea pig after noise exposure[J];Journal of Jilin University(Medicine Edition);2006-02
10 LI Hong-kun,YU Xiao-feng,QU Shao-chun,XU Hua-li,SUI Da-yuan~(Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China);Protective effects of Diemailing Injection on experimental myocardial infarction in rats and its mechanism[J];Journal of Jilin University(Medicine Edition);2006-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Tang Tao, Cheng Yongfu et al. Medical Department of Anhui Provincial Hospital, Hefei;METHOD OF DETERMINATION FOR PLASMA CATECHO LAMINELEVEL[J];Anhui Medical Journal;1989-03
2 MA Jing1, FU Nai yang2, LI Yu mei3, PENG Wen lie1, XU An long1*1.Department of Biochemistry and Center for Biopharmaceutical Research, College of Life Science, Zhongshan University, Guangzhou 510275, P.R.China2.Institute for Drug Control of Guangdong;Glycyrrhiza uralensis Fisch Extract Selectively Induces Apoptosis in Several Human Cancer Cell Lines in Vitro[J];Chinese Journal of Cancer;2001-08
3 Weng Xi Yang, Ma Run Di, Yu Li Jian Guangdong Provincial Key Laboratory of Marine Materia Medica,Zhanjiang Ocean University,Zhanjiang, Guangdong,524025,P.R.China;Apoptosis of Human Nasopharyngeal Carcinoma CNE-2Z Cells Induced by Tubeimoside Ⅰ[J];Chinese Journal of Cancer;2003-08
4 MA Rui,XU Huan,YANG Li-li,CHENG Liang,TANG Yun-guo,YE Yun(Grade 2001,Faculty of Medicine,Bengbu Medical College,Bengbu 233030,China);Protective effect of acanthopanax senticosus injection on the acute myocardial anoxia in mice[J];Journal of Bengbu Medical College;2006-01
5 Hong Xingqiu, et al(Institute of Molecular Medicine, Hangzhou 310009);Experimental Study of Pinellia Tuber on Reducing Blood-Lipid[J];Journal of Zhejiang College of Tcm;1995-02
6 Wo xingde; Gao Chenxian;Hong xingqiu et al(Institution of Molecular Medicine, Zhejiang College of TCM, Hangzhou 310009);Experimental Study about the Extracts of Turmerol in Dietary Rabbit with Hyperlipemia[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;1999-01
7 Gao Bo, Fan Chunlei, Bao Ruimei Zhejiang College of Traditional Chinese Medicine,Hangzhou(310053);Study on Effect of Curcumin on the Expression of Mouse Macrophage LDl Receptor[J];Journal of Zhejiang College of Tcm;2005-01
8 LI Xiang-Hua1,ZHOU Liang2,HE Xiao-zhi3,TANG Xiang-bin4,PENG Yu1(1.P.E.Department,Hunan Institute of Science and Technology, Yueyang 414006,Hunan,China;2.Graduate School,Beijing Sport University,Beijing 100084,China;3.Changsha University of Science and Technology,Changsha 410071,Hunan China;4.Physical Education Department,Hunan Normal University,Changsha 410081,Hunan China);The Effects of Gynostemmapentaphyllum on Experimental Hyperglycemia Rats' Plasma Lipoprotein Metabolism and Their Related Enzyme Activity[J];Journal of Beijing Sport University;2007-02
9 Li Hongzhen, Zhou Xiang(Department of Biochemistry);Relationship between monoamine mediator metabolism of the brain and aging in rats[J];;1990-01
10 ZHANG Man ying,AN Ji hong,LI Chang hui (Dept.of Respiration,The Second Hospita,Jilin University,Changchun 130021 China);Study on apoptosis of Spc-A_1 cell induced by acanthophopanax senticosus[J];Journal of Norman Bethune University of Medical Science;2002-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 ZHAO Xue-zhong~1, ZHANG Zhi-guo~1,WANG Ye-ling~1, CAO Xia~2, YU Xiao-feng~2, XU Hua-li~2, QU Shao-chun~2,SUI Da-yuan~2(1. Department of Cardiovascular Medicine, First Hospital, Jilin University, Changchun 130021,China;2. Department of Pharmacology, School of Pharmacy,Jilin University,Changchun 130021,China);Protective effects of Fosinopril on myocardial ischemia-reperfusion injury in rats[J];Journal of Jilin University of (Medicine Edition);2005-04
2 LIU Jin-ping, ZHAO Chun-fang, LI Ping-ya , LI Xian ( Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang 110015, China; Department of New Drug, Institute of Froniter Medical Sciences, Jilin University, Changchun 130021, China; Department of Pharmaceutical analysis, Jilin University, Changchun 130021, China);Ameliorative effects of pseudoginsenoside GQ on isoproterenol-induced acute myocardial ischemia in rats[J];Journal of Jilin University(Medicine Edition);2006-01
3 ZHANG Yan-rong~1,SHAN Yu-ling~1,LI Yu~(2*)(1.College of Food Engineering,Jilin Agricultural University,Changchun 130118,China;2.College of Agronomy,Jilin Agricultural University,Changchun 130118,China);Action of lowering blood fat of Agaricus blazei Murill ω-6 polyunsaturated fatty acid on hyperlipemia rats and mice[J];Journal of Jilin University(Medicine Edition);2006-06
4 CHEN Dong-mei1,SUI Cheng2,QU Shao-chun1,XU Hua-li1,HE Xiao-xi1,WANG Xuan-hui1,YU Xiao-feng1(1.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China;2.Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University,Nanjing 210038,China);Effect of Injection of Ginseng Fruit Saponins on experimental hyperglycemia[J];Journal of Jilin University(Medicine Edition);2007-04
5 QU Shao-chun1,SUI Cheng1,2,YU Xiao-feng1,WANG Xuan-hui1,HE Xiao-xi,XU Hua-li1(1.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China;2.Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University,Nanjing 210038,China);Protective effects of Ginsenoside-Rb on experimental myocardial ischemia-reperfusion injury in rats[J];Journal of Jilin University(Medicine Edition);2007-05
6 WANG Da-wei,XU Xiu-ying,LIU Ting-ting(College of Food Engineering,Jilin Agricultural University,Changchun 130118,China);Action of corn filament beverage on falling blood fat in hyperlipemia rats and mice[J];Journal of Jilin University(Medicine Edition);2007-06
7 LIU Leng1,2,XU Hua-li1,YU Xiao-feng1,QU Shao-chun1,LIANG Qi-ming1,SUI Da-yuan1(1.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China;2. Institute for Microorganism control,Center of Disease Control and Preventionin,Guangdong Province,Guangzhou 510300,China);Protective effects of Kudiezi Oral Solution on experimental hyperlipoproteinemia in rats[J];Journal of Jilin University(Medicine Edition);2008-05
8 Kang Yihua College of Pharmacy,Heilongjiang University of TCM(Harbin 150040,China);Quality Evaluation of Wild and Cultivated Radix Caulis Acanthopanacis Senticosi Leaves[J];Heilongjiang Medical Journal;2005-06
9 JI Chen-feng1,XIAO Feng2 (1.Center of Research on Life Sciences and Environmental Sciences,Harbin University of Commerce,Harbin 150076,China;2.Engineering Research Center of Natural Anticancer Drugs,Ministry of Education,Harbin 150076,China);Effect of Qinglongyi polysaccharide on membrane components and fluidity of S_(180) mice[J];Journal of Harbin University of Commerce(Natural Sciences Edition);2008-04
10 LIANG Jie1,HUANG Bao-kang2*(Fujian University of Traditional Chinese Medicine Fuzhou 350108;The Second Mililary Medical University Shanghai 200433);Antioxidant activity and Protective effects of Flavonoids against Myocardial Ischemia Reperfusion[J];Strait Pharmaceutical Journal;2010-11
China Proceedings of conference Full-text Database 1 Hits
1 Qiushi GUO~b,Min WU~b,Yuanyuan REN~b,Zhiheng JIANG~a,Xiuhua HAO~a,Zhiying DING~a, a School of Pharmaceutical Sciences,Jilin University;China b Postgraduate,Jilin University;China;The Study of β-cyclodextrin and TFAD Supramolecular Inclusion Complex[A];[C];2010
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 LU Zhong-Zhi, JIN Yi, ZHO Min, YU Xiao-Feng Wept. Phar. ,Bethune University of Medical Sciences .Changchun. 130021);Effects of PQS on cardiohemodynamics in anaesthetia dogs and myocardial infarct dogs[J];Chinese Pharmacological Bulletin;1992-03
2 Tian Baojie Gao Tianli(Section of Physiology, Dept of Biology, Peking University) Song Zhengliang(Harbin Second Chinese Medicine Factory);Effects of Ciwujia(Acanthopanax senticosus Harms) on Reperfusion Induced Arrhythmias and Action Potential Alterations in Isolated Rat Heart[J];China Journal of Chinese Materia Medica;1989-08
3 Sui Dayuan; Lu Zhongzhi; Yu Xiaofeng;Wang Li(Department of Pharmacology,Bethune University of Medical Sciences,Changchun,130021);Effects of Yixin Oral Liquid on Myocardial Infarct Size and Hemorheology in Rats with Acute Myocardial Ischemia[J];CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE;1996-03
4 Sui Dayuan. Yu Xiaofeng. Lu Zhongzhi. at al(Dept. of Pharmacol. N. Bethune Univ. of Med. Sci . Changchun 130021 );Hemodyamic effects of LGE on anaesthetized dogs[J];PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA;1994-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved