Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Jilin University of (Medicine Edition)》 2004-01
Add to Favorite Get Latest Update

Effects of Acanthopanax senticosus saponins on ventricular remodeling in rats with acute myocardial infarction

LIU Leng 1,SUI Da yuan 1* , QU Shao chun 1,YU Xiao feng 1, WANG Zhi cai 2,CHEN Yan ping 2 (1. Department of Pharmacology, School of Pharmacy, Jilin University,Changchun 130021, China; 2. Department of Nature Medical Chemistry , School of Chemistry, Jilin University, Changchun 130021, China)  
Objective\ To investigate effects of Acanthopanax senticosus saponins (ASS) on ventricular remodeling in rats with acute myocardial infarction. Methods The myocardial infarct model was induced by left anterior descending coronary occulusion in rats. After 4 weeks of treatment by ASS, hemodynamic changes, biochemical analysis and morphological parameters were determined in ventricular remodeling rats. Results The maximum left ventricular presure rising and dropping rates (±dp/dt max ) and their left ventricular systolic pressure corrected values(±dp/dt max /LVSP) were increased significantly. The left ventricular end diastolic pressure (LVEDP), the left ventricular volume (LVV), the left ventricular long and short axis(LVLA and LVSA), the left ventricular absolute and relative weight (LVAW and LVRW) were reduced significantly, but there were no significant influences on the right ventricular absolute and relative weight (RVAW and RVRW), the heart rate (HR), the left ventricular systolic pressure (LVSP), mean artery pressure (MAP) and body weight (BW). In addition, the serum lipid peroxidation (LPO) content, myocardial angiotensin Ⅱ (AngⅡ) and epinephrine (E) contents were declined, superoxide dismutase (SOD) and glutathione peroxidase (GSH Px) activities were increased markedly. Conclusion ASS can prevent and treat ventricular remodeling after myocardial infarction in rats efficiently.
【Fund】: 吉林省科技厅重点课题 (吉科合字 1 9890 31 0 - 0 5 ) ;; 吉林省中医药管理局科研基金重点课题 (合同号 98A1 7)
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 8 Hits
1 SUI Da-yuan 1, YU Xiao-feng1,QU Shao-chun1, ZHAO Xue-zhong2 (1. Department of Pharmacology, School of Pharmacy, Jilin University,Changchun 130021,China; 2. Department of Cardiovascular Medicine, First Hospital, Jilin University, Changchun 130021,China);Effects of Acanthopanax senticosus saponins on myocardial ischemia-reperfusion arrhythmia in rats[J];Journal of Jilin University of (Medicine Edition);2004-04
2 HAN Xiang-dong,CHEN Chang-xun~*(Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China);The Advance on the Experimental Studies of Myocardial Hypertrophy Treated by Materia Medica[J];LiShiZhen Medicine and Materia Medica Research;2005-12
3 WANG Tian-xiao1,2,YU Xiao-feng1,QU Shao-chun1,XU Hua-li1,HAN Dong1,SUI Da-yuan1(1.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China;2.Institute of Pharmaceutical Research,School of Pharmacy,Henan University,Kaifeng 475004,China);Effect of Ginsenoside-Rb on Ventricular Remodeling in Rats with Pressure Overloaded Hypertrophic Myocardium and its Mechanism[J];Lishizhen Medicine and Materia Medica Research;2008-07
4 YU Da-hai1,MAO Shi-long2(1.Department of Pharmacy,No.404 Hospital of PLA,Weihai 264200,China;2.Department of Pharmacy,Xuhui District Central Hospital of Shanghai,Shanghai 200031,China);Protective effect of Acanthopanax senticosus saponins against acute myocardial infarction in anesthetized dogs[J];Pharmaceutical Care and Research;2008-05
5 YU Da-hai(The 404th Hospital of PLA,Weihai 264200,China);Effects and mechanism of Acanthopanax senticosus saponins on myocardial ischemia and reperfusion in rats[J];Journal of Pharmaceutical Practice;2008-03
6 YU Da-hai~1 MAO Shi-long~2 (1.The 404th Hospital of PLA,Weihai 264200,China;2.Department of Pharmacy,Xuhui District Central Hospital,Shanghai 200031,China);Effects of acanthopanax senticosus saponins on platelet,blood coagulation and blood viscosity in rabbits[J];Journal of Pharmaceutical Practice;2008-04
7 HUANG Wei,LI Guixia,XIE Yan,QI Hanping Department of Pharmacology,Daqing Campus of Harbin Medical University,Heilongjiang Province,Daqing 163319,China;Analysis of the myocardial protection effects and mechanism of Acanthopanax Senticosus[J];China Medical Herald;2011-32
8 LIANG Qiming,QU Shaochun,YU Xiaofeng,XU Huali,SUI Dayun(Department of Pharmacology,School of Pharmaceutical Sciences,Jilin University,Changchun 130021,China);Acanthopanax senticosus saponins ameliorates oxidative damage induced by hydrogen peroxide in neonatal rat cardiomyocytes[J];China Journal of Chinese Materia Medica;2009-19
【Citations】
Chinese Journal Full-text Database 5 Hits
1 Tang Tao, Cheng Yongfu et al. Medical Department of Anhui Provincial Hospital, Hefei;METHOD OF DETERMINATION FOR PLASMA CATECHO LAMINELEVEL[J];Anhui Medical Journal;1989-03
2 Li Hongzhen, Zhou Xiang(Department of Biochemistry);Relationship between monoamine mediator metabolism of the brain and aging in rats[J];;1990-01
3 HUANG Jing 1, LIU Zhi ting 1, LIU Xiao dong 2 (1. Dept.of Laboratory,The First Hospital, Jilin University,Changchun 130021,China; 2. MH Radiobiology Research Unit,School of Public Health,Jilin University) [;Effect of Buckthorn on Cativity of SOD and Expression of SOD mRNA in Elder Rats[J];Journal of Jilin University of (Medicine Edition);2003-05
4 Zhang Pei,Yang Yuejin,Song Laifeng,et al. Department of Coronary Heart Disease,Cardiovascular Institute and Fu Wai Hospital,CAMS and PUMC,Beijing(100037);Comparison of Effects of High,Middle and Low Doses of Enalapril in Prevention of Left Ventricular Remodeling after Acute Myocardial Infarction in Rats[J];Chinese Circulation Journal;2001-04
5 Sui Dayuan; Lu Zhongzhi; Yu Xiaofeng;Wang Li(Department of Pharmacology,Bethune University of Medical Sciences,Changchun,130021);Effects of Yixin Oral Liquid on Myocardial Infarct Size and Hemorheology in Rats with Acute Myocardial Ischemia[J];CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE;1996-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Hong-liang et al(Pharmacy College,Gannan Medical University,Ganzhou,Jiangxi 341000);Effect of Genistein on Hemodynamics of Myocardial Ischemia Rats[J];Journal of Anhui Agricultural Sciences;2011-08
2 YU Xiao feng 1, QU Shao chun 1,XU Hua li 1,SUI Da yuan 1,CHEN Yan ping 2, MA Xing yuan 2 (1. Dept.of Pharmacology,Pharmacy College, Jilin University ,Changchun 130021, China; 2. Dept.of Chemistry ,Chemical College, Jilin University) [;Protective Effect of GFS on Experimental Myocardial Infarction in Rats[J];Journal of Jilin University of (Medicine Edition);2003-05
3 HU Bing,YU Xiao feng,QU Shao chun,XU Hua li,SUI Da yuan * (Dept. of Pharmacology, School of Pharmacy,Jilin University, Changchun 130021, China);Protective Effect of FJDP on Acute Myocardial Ischemia in Rats[J];Journal of Jilin University of (Medicine Edition);2003-06
4 SUI Da-yuan 1, YU Xiao-feng1,QU Shao-chun1, ZHAO Xue-zhong2 (1. Department of Pharmacology, School of Pharmacy, Jilin University,Changchun 130021,China; 2. Department of Cardiovascular Medicine, First Hospital, Jilin University, Changchun 130021,China);Effects of Acanthopanax senticosus saponins on myocardial ischemia-reperfusion arrhythmia in rats[J];Journal of Jilin University of (Medicine Edition);2004-04
5 CHEN Yue 1, WANG Bao-gui 2, ZHANG Gui-ying 2, YAN Wei-qun 3 (1. Department of Pharmacy Analysis,School of Pharmacy,Jilin University,Changchun 130021,China; 2. Department of Nutrition and Food Hygiene,School of Public Health,Jilin University, Changchun 130021,China; 3. Department of Biochemistry,Institute of Frontier Medical Sciences,Jilin University, Changchun 130021,China);Protective effects of acanthopanax senticosus saponins on mice with irradiation damage induced by X-rays[J];Journal of Jilin University of (Medicine Edition);2005-03
6 LI Hong-kun,YU Xiao-feng,QU Shao-chun,XU Hua-li,SUI Da-yuan~(Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China);Protective effects of Diemailing Injection on experimental myocardial infarction in rats and its mechanism[J];Journal of Jilin University(Medicine Edition);2006-02
7 SUN Ming-li,LIU Xiao-liang,DONG Jun-shu (Department of Emergency,First Hospital,Jilin University,Changchun 130021,China);Effects of valsartan on left cardiac function and vasoactive substance after acute myocardial infarction in rats[J];Journal of Jilin University(Medicine Edition);2007-04
8 ZHAO Ji lan, YU Shu guang, ZHOU Qi zhi, et al (赵纪岚,等) Acupuncture, Moxibustion and Tuina College, Chengdu University of TCM (Chengdu, 610075,China);Influence of Acupuncture to the Contents of Neurotransmitter in Central Nervous System of Senile Rats and Mice[J];JOURNAL OF CHENGDU UNVERSITY OF TARDITIONAL CHINESE MEDICINE;1999-03
9 Yuang Ling,Bo Feng,Zhang Yong-he*(Changchun University of TCM,Changchun 130021,China);The Effection of Cornu Cervi on the content of SOD,MDA during the later stage of Acute Myocardial Ischemic in Rat.[J];Journal of Changchun University of Traditional Chinese Medicine;2007-01
10 TIAN Gang1,2,SUI Da-yun1,SI Xin1,QU Shao-chun1,FU Wen-wen1,YU Xiao-feng1(1.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China; 2.Pharmaceutical Factory,Norman Bethune University of Medical Sciences,Changchun 130012,China);Protective effect of panax quinquefolium 20s-protopanaxtriolsaponins on acute myocardial infarction in rats[J];Journal of Jilin University(Medicine Edition);2012-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WANG Xin,HAI Chun-xu,LIANG Xin(Department of Toxicology,School of Military Preventive Medicine,the Fourth Military Medical University,Xi'an 710032,China);Activities of Acanthopanax Extracts in Vitro in Free Radical Models[J];Carcinogenesis,Teratogenesis & Mutagenesis;2009-02
2 Chu Jun,Xu Meiqing,He Hua,et al Department of Cardiology,Anhui Provincial Hospital,Hefei 230001;Experimental study of acute myocardial infarction model in dogs[J];Anhui Medical Journal;2002-02
3 XU Xiao hong,DONG Chang wu,LIAO Sheng bao Tutor:Professor GAO Er xin (Anhui College of TCM,Anhui Hefei 230038,China);EXPERIMENTAL STUDY ON THE TREATMENT OF YIN DEFICIENCY TYPE HYPERTENSION DISEASE WITH ZISHUI JIANGHUO DRINK[J];Journal of Anhui Traditional Chinese Medical College;2001-06
4 Liang Xinglun,Han Mingxiang,Xu Zhaofang et al;Clinical Study on Insulin Resistance Syndrome Treated with Si'an Capsule[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;1997-01
5 YANG Lin1,DUAN Peng-fei2,WANG Qiong2,YUAN Fa-ping2*(1.Maternity department,Baoan people's hospital,Shenzhen 518001;2.College of pharmacy,Wuhan University,Wuhan 430072,China);Analgesic,Antitumor Research and Isolation,Analysis of Extracted Compound from Venenum bafonis[J];Amino Acids & Biotic Resources;2007-01
6 CAI ZHI-RONG,WANG LI-HONG,GONG HUI-PING,et al (Department of Geriatrics,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);EFFECTS OF VALSARTAN ON VENTRICULAR REMODELING IN RATS WITH PRESSURE OVERLOAD-INDUCED HEART FAILURE[J];Acta Academiae Medicinae Qingdao Universitatis;2010-01
7 Wang Yu, Huang Jianqun, Xie Miaorong, et al (Department of Emergency, Beijing Friendship Hospital, Beijing 100050);Effect of herbal compound 861 on myocardial fibrosis after acute myocardial infarction in rats[J];Beijing Medical Journal;2005-02
8 Li Ying 1,Cui Xinming 1,Pan Li 1,Li Zhenbao 1,Ji Chongde 2,Du Kuiqin 3 (1\ Dept.of Electron Microscopy;2\ Dept.of General Surgery,The Third Clinical College;3\ Dept.of Pathophysiology);Electron microscopic observation and Ca~(2+) analysis on protective effect of ginsenoside from fruit on myocardium of hemorrhagic shock in dogs[J];Journal of Norman Bethune University of Medical Science;1998-05
9 YU Xiao feng 1, QU Shao chun 1,XU Hua li 1,SUI Da yuan 1,CHEN Yan ping 2, MA Xing yuan 2 (1. Dept.of Pharmacology,Pharmacy College, Jilin University ,Changchun 130021, China; 2. Dept.of Chemistry ,Chemical College, Jilin University) [;Protective Effect of GFS on Experimental Myocardial Infarction in Rats[J];Journal of Jilin University of (Medicine Edition);2003-05
10 HU Bing,YU Xiao feng,QU Shao chun,XU Hua li,SUI Da yuan * (Dept. of Pharmacology, School of Pharmacy,Jilin University, Changchun 130021, China);Protective Effect of FJDP on Acute Myocardial Ischemia in Rats[J];Journal of Jilin University of (Medicine Edition);2003-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 XI Ying1,TAO Ming-fei2,WANG Yuan-yuan2,TAO Jing2(1.Department of Pharmacy,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004; 2.Function Experimental Centre,Bengbu Medical College,Bengbu Anhui 233030,China);The effect of acanthopanax senticosus injection on intestinal propulsive and gastric emptying function in mice of gastrointestinal dysfunction[J];Journal of Bengbu Medical College;2012-04
2 ZHAO Xue-zhong~1, ZHANG Zhi-guo~1,WANG Ye-ling~1, CAO Xia~2, YU Xiao-feng~2, XU Hua-li~2, QU Shao-chun~2,SUI Da-yuan~2(1. Department of Cardiovascular Medicine, First Hospital, Jilin University, Changchun 130021,China;2. Department of Pharmacology, School of Pharmacy,Jilin University,Changchun 130021,China);Protective effects of Fosinopril on myocardial ischemia-reperfusion injury in rats[J];Journal of Jilin University of (Medicine Edition);2005-04
3 LIU Jin-ping, ZHAO Chun-fang, LI Ping-ya , LI Xian ( Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang 110015, China; Department of New Drug, Institute of Froniter Medical Sciences, Jilin University, Changchun 130021, China; Department of Pharmaceutical analysis, Jilin University, Changchun 130021, China);Ameliorative effects of pseudoginsenoside GQ on isoproterenol-induced acute myocardial ischemia in rats[J];Journal of Jilin University(Medicine Edition);2006-01
4 TIAN Gang1,2,SUI Da-yun1,SI Xin1,QU Shao-chun1,FU Wen-wen1,YU Xiao-feng1(1.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China; 2.Pharmaceutical Factory,Norman Bethune University of Medical Sciences,Changchun 130012,China);Protective effect of panax quinquefolium 20s-protopanaxtriolsaponins on acute myocardial infarction in rats[J];Journal of Jilin University(Medicine Edition);2012-04
5 LIU Yan-ze,CHEN Shi-lin,MA Pei,XIAO Pei-gen Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China;Ways to find new anticancer drugs from Chinese herbal medicines[J];Drugs & Clinic;2012-04
6 BI Yun-Feng1,2,ZHU Hong-Bin1,PI Zi-Feng1,LIU Zhi-Qiang1,SONG Feng-Rui1(1.Chemical Biology Laboratory,Changchun Center of Mass Spectrometry,Changchun Institute of Applied Chemistry, Chinese Academy of Sciences,Changchun 130022,China; 2.College of Food Science and Engineering,Jilin Agricultural University,Changchun 130118,China);Effects of Flavonoides from the Leaves of Acanthopanax on the Activity of CYP450 Isozymes in Rat Liver Microsomes by a UPLC-MS/MS and Cocktail Probe Substrates Method[J];Chemical Journal of Chinese Universities;2013-05
7 Han Xibin;Xie Jianzhong;Ba Caifeng;;Effects of compound Chinese herbal medicine on the expression of HSP70 in liver,jejunum and ovary of layers under chronic heat stress[J];Feed Industry;2014-14
8 Kang Yihua College of Pharmacy,Heilongjiang University of TCM(Harbin 150040,China);Quality Evaluation of Wild and Cultivated Radix Caulis Acanthopanacis Senticosi Leaves[J];Heilongjiang Medical Journal;2005-06
9 Guo Zhihua,Bin Xiaofang,Mao Xiangping,Liu Yehui,Liu Wenpin(The second affiliated hospital of hunan traditional chinese medicine university,Hunan Changsha 410005);The benefit of heart after myocardial infarction rats function and mechanism of the ventricular remodeling[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2011-09
10 LIAO Jing-jing,XU Jian-guo,YANG Wei-jun,et al.Xinjiang Institute ofMateria Medica/Key Laboratory ofXinjiang Uygur Medicine,Urumqi 830004,China;Antioxidant activity and hypoxia-reoxygenation injury protective effects of flavonoids from Ziziphora clinopodioideson neonatal rat cardiomyocytes[J];Global Traditional Chinese Medicine;2011-04
China Proceedings of conference Full-text Database 3 Hits
1 ;刺五加临床应用拓展研究[A];[C];2011
2 Zheng Jing;Zhang Gui-jun;Beijing University of Chinese Medicine;;Research progress of chemical components and pharmacological effects on Cortex Acanthopanacis senticosi radix et rhizome seu caulis[A];[C];2015
3 ZHANG Bei-yue;WEI Yong-heng;SHI Jin-li;Beijing University of Chinese Medicine;;Research Progress of the Chemical Constituents and Pharmacological Effects of Leaves of Acanthopanax senticosus(Rupr.et Maxim.) Harms.[A];[C];2015
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved