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Effects of Sanshen Ziwei Yin on G cells and D cells of gastric mucosa in rats with chronic atrophic gastritis

LI You tian 1* , XU Dan 1, ZHAO Li 1,LI Hong lin 1, DONG Yu xiang 1, HONG Ying jie 1 ZHANG Er li 1, ZHANG Dian jun 1,XU Cai yun 2, GAO Wen yan 1, HUO Yu ping 1, LI Qiu bo 1,LI Xiao chun 1 (1. Department of Chinese Traditional Medicine,First Hospital, Jilin University, Changchun 130021,China;2. Department of Animal Laboratory, School of Basic Medical Sciences,Jilin University,Changchun 130021,China)  
Objective To study the effects and mechanisms of Sanshen Ziwei Yin(SZY) on D cells and G cells of gastric mucosa in rats with chronic atrophic gastritis (CAG). Methods Rat models with CAG were established with synthesis method (active immunity,cold and cool gall and hot water irrigation). High and low dose of SZY and Weimeisu (WMS,as control) were used for 50 days constantly. The pathological changes of gastric mucosa,morphological and number changes were observed before and after treatment. Results The number of G cells and D cells of rats with CAG decreased significantly ( P 0 01), and degranulation presented in both two kinds of cells. The decrease of G/D ratio indicated that G cells descented more fast than D cells, that is to say, G cells were more sensitive to CAG. After treatment,the number of D cells increased obviously in treatment group, and apporached to normal levels at last,there was significant difference compared with WMS group. Conclusion SZY may have therapeutic effects on CAG through improving the inflammatory reaction of gastric mucosa to promote the regeneration of gland, endocrine and paracrine cells,and improving the regulation effects of gastrointestinal hormones on gastric function.
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