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《Journal of Jilin University of (Medicine Edition)》 2004-02
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Study on antagonism of ginsenoside to toxicity of embryo development induced by acetic lead in rat

ZOU Ji yan 1,WANG Xue gong 2,HUANG Bing yu 3,LI Shou rou 3,HU Jing 3,LIU Li juan 3(1. Department of Obstetrics and Gynecology, China Japan Union Hospital, Jilin University,Changchun 130031, China; 2. Improving Birth Outcome and Child Development Center, No 208 Hospital of PLA,Changchun 130051,China;3. Department of Obstetrics and Gynecology, Second Hospital, Jilin University,Changchun 130041,China)  
ObjectiveTo explore the antagonism of ginsenoside to the toxicity of embryo development induced by acetic lead in rat. MethodsThe embryo teratogenic model in rat was established by whole embryo culture in vitro , antagonistic experiment was made with ginsenoside. ResultsAcetic lead had stronger developmental toxicity on rat embryo and the relationship of dose effect was demonstrated, the developmental toxicity on rat embryo could be antagonized by ginsenoside. Ginsenoside could ensure normal growth of rat embryo. ConclusionGinsenoside has better antagonism on embryo teratism in rat induced by acetic lead and can proportionately promote the differentiation and development of rat embryo.
【Fund】: 卫生部科学研究基金 (98- 2 - 1 86 )
【CateGory Index】: R285
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