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《Journal of Jilin University of (Medicine Edition)》 2004-03
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Effects of IFN-PDS on T-lymphocyte proliferation in influenza virus-infected mice

CAO Jie 1, SUN Lian kun 1, CHENG Xiao geng 2, MAO Jian hua 1, LIU Xi chun 1, WANG Cheng 2, LI Yang 1, ZHAO Xue jian 1 (1.Department of Phathophysiology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China;2.Insititute of Biological Products of Changchun, Changchun 130062,China)  
Objective To investigate the effects of interferon panaxadiol saponins (IFN PDS) on the function of T lymphocyte proliferation in influenza virus infected mice. Methods 60 Kunming mice were divided into 5 groups: control group(ConG),influenza virus infected group (VIG),PDS treatment group(PDSG),IFN treatment group (IFNG),IFN PDS treatment group(IFN PDSG). Mouse adopted influenza virus A was used to construct virus infected model. The functions of T lymphocyte proliferation in spleen and thymus gland were observed by MTT assay. Results ①The spleen index of VIG was much greater than that of ConG( P 0 01). The mitogenesis induced by ConA of thymocyte and splenocyte was higher than that in ConG ( P 0 05). ②Self proliferations of splenocytes in PDSG,IFNG, and IFN PDSG were significantly higher than that in VIG( P 0 01, P 0 05, P 0 05). The mitogenesis induced by ConA of splenocytes in PDS and IFN PDSG were lower than that in VIG ( P 0 05, P 0 01). ③The mitogenesis induced by ConA of thymocytes in PDSG,IFNG, and IFN PDSG were lower than that in VIG ( P 0 01, P 0 05, P 0 05),had no difference compared with ConG( P 0 05). Conclusion Influenza virus can stimulate the proliferation of spleen and thymic T lymphocyte directly. It can increase the T lymphocyte mitogenesis induced by ConA obviously. PDS and IFN PDS treatment can increase the self proliferation of splenocyte in influenza virus infected mice, and decrease the excessive mitogenesis of splenocyte and thymocyte induced by ConA. It has two way modulation on the function of T lymphocyte.
【Fund】: 吉林省科技发展计划抗非典重点项目 (2 0 0 30 5 0 1 )
【CateGory Index】: R96
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