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《Journal of Jilin University of (Medicine Edition)》 2004-03
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Effects of Acanthopanax senticosus saponins(ASS) on hemorrheology and platelet function in experimental cerebral ischemia rats

JIANG Hong yu 1,SUI Da yuan 1 ,YU Xiao feng 1,QU Shao chun 1,XU Hua li 1,WANG Zhi cai 2,CHEN Yan ping 2 (1.Department of Pharmacology, School of Pharmacy, Jilin University,Changchun 130021, China; 2.Department of Nature Medical Chemistry, School of Chemistry, Jilin University, Changchun 130021, China)  
Objective To observe the effects of Acanthopanax senticosus saponins (ASS) on hemorrheology and platelet function in experimental cerebral ischemia rats. Methods The cerebral ischemia model induced by bilateral common carotid artery clamping and controlled hemorrhage to a mean arterial pressure of 50 mmHg was produced in rats treated by continuous intraperitoneal injection of ASS with dosages of 25,50,100 mg·kg -1 for 3 days. The effects of ASS on the hemorrheology and platelet aggregation and adhesion functions were measured after 15 min. Results ASS with dosages of 50 and 100 mg·kg -1 decreased the blood viscosity,plasma viscosity, plasma fibrinogen concentration,erythrocyte sedimentation,hematocrit, erythrocyte aggregation index, and erythrocyte rigidity index markedly,and inhibited platelet aggregation and adhesion functions. Conclusion ASS can improve evidently abnormal changes of hemorrheology and platelet functions in experimental cerebral ischemia rats.
【Fund】: 吉林省科技厅重点课题 (1 9890 31 0 - 0 5 ) ;; 吉林省中医管理局科研基金重点课题 (98A1 7)
【CateGory Index】: R285
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