Effect of selenium on lipid peroxidation damage in children with acute viral myocarditis
ZHENG Bai hong, YU Ming tao, ZHENG Bai bo △, JIANG Gui ying (Department of Pediatrics, Second Hospital, Jilin University, Changchun 130041, China)
Objective To study the action of oxygen free radical (OFR) in pathogenesis of acute viral myocarditis (AVMC) and the therapeutic effect of selenium (Se) on myocardium damaged by OFR. Methods Se in serum, superoxide dismutase (SOD), glutathione peroxidase (GSH P X),malonadelye (MDA) were detected in children, which included 60 cases of AVMC children and 60 healthy children as control, respectively. Children with AVMC were randomly divided into routine treatment group (30 cases) and Se supplemented group (30 cases). Se supplemented and routine treatment (anti viruses, immune system modulation, myocardium nourishing) were used in Se supplemented group. Only routine treatment was used in routine treatment group. The treatment period was 4 weeks. Through observation of changes of Se in serum, GSH P X,SOD,MDA,enzyme of myocardium, ECG and clinical symbols before and after treatment in two groups, the curative effects were assessed. Results OFR and LPO reactions appeared pathological changes in children with AVMC. Se in serum,SOD,GSH P X were decreased ( P 0 001) and MDA was increased ( P 0 001) in children with AVMC. After treatment with Se supplemented, Se in serum, SOD,GSH P X activities were significantly increased ( P0 01, P0 01, P 0 001)and MDA content was significantly decreased ( P 0 001), compared with before treatment, and all of the clinical symbols were disappeared. Enzymes of myocardium were normal. The percentage of ECG normalization was significantly higher than that of the routine treatment group ( P 0 05). The curative rate of AVMC was increased. Conclusion Se is effective to clear OFR and able to protect myocardium through inhibiting OFR and LPO reaction. On the basis of routine treatment for viral myocarditis, Se supplemented is more effective than routine treatment.