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《Journal of Jilin University of (Medicine Edition)》 2004-04
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Effects of ginsenoside Rg_2 on hemodynamics and oxygen metabolism in narco-canine with acute cardiogenic shock

LU Wen-wei1, LIU Jie1, ZHAO Li-juan1,TIAN Jian-ming2, LI Long-yun2, YANG Shi-jie 1 (1. Department of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China; 2.Academy of Traditional Chinese Medicine and Materia,Jilin Prorince, Changchun 130021,China)  
Objective To investigate the effects of ginsenoside Rg 2 on hemodynamics and oxygen metabolism in narco-canine with acute cardiogenic shock. Methods Model of acute cardiogenic shock was made by ligating left anterior descending branch of coronary artery(LAD). Hemodynamics and oxygen metabolism in narco-canine were observed after administrated with 2 and 1 mg·kg -1 ginsenoside Rg 2. Results Ginsenoside Rg 2 increased mean blood pressure (MBP),left ventricular systolic pressure (LVSP),±dp/dt max,and cardiac output (CO), remarkably, and reduced the exponent of oxygen consuming of myocardium and the rate of oxygen intake of myocardium compared with control group. Conclusion Ginsenoside Rg 2 has therapeutical effect on acute cardiogenic shock in canine.
【Fund】: 国家科技部资助课题 (95 10 35 )
【CateGory Index】: R285
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