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《Journal of Jilin University of (Medicine Edition)》 2004-04
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Inhibitory effect of 20(S)-ginsenoside Rg_3 on B16 melanoma metastasis

XIN Ying,NI Jin-Song,WANG Xin-Rui,SHI Bo, WANG Yue-Hui, WU Jia-Xiang (Department of Pathology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China)  
Objective To study the inhibitory effect of 20(S)-ginsenoside Rg 3 on B16 melanoma metastasis and its mechanism. Methods The spontaneous and experimental lung metastasis models of B16 melanoma were used to investigate the inhibitory effects of Rg 3 on tumor metastasis. The assay of tumor-induced angiogenesis was used to observe the effect of ginsenoside Rg 3 on B16 melanoma angiogenesis. The effect of Rg 3 on invasive ability of B16 cells in vitro was detected by Boyden chamber. Results In the spontaneous and experimental lung metastasis models of B16 melanoma, the number of tumor colonies in lung in each Rg 3 group was lower than that in control group. The number of vessels oriented toward the tumor mass and the invasive ability of B16 cells decreased obviously after treated with Rg 3. Conclusion 20(S)-ginsenoside Rg 3 can obviously inhibit the lung metastasis of B16 melanoma. The inhibitory effect partially dues to its inhibiting angiogenesis induced by B16 melanoma and decreasing the invasive ability of B16 cells.
【Fund】: 吉林省科技厅科技发展计划项目资助课题 (990 5 75 - 5 )
【CateGory Index】: R285
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