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《Journal of Jilin University of (Medicine Edition)》 2004-05
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Effects of sodium butyrate on cell growth inhibition and apoptosis in PC-3M cell lines

DI Qian 1, LI Yang 1, ZHAO Xue-jian 1 , MIYAGI Taeko 2 (1. Department of Pathophysiology , School of Basic Medical Sciences,Jilin University,Changchun 130021, China;2. Miyagi Prefectural Cancer Center,Miyagi 981-1293,Japan)  
Objective To investigate the effects of sodium butyrate on cell growth inhibition and apoptosis in PC-3M cell lines. Methods Sodium butyrate was added to the culture media of PC-3M cells for different hours and then the cell changes were observed by phase-contrast microscope, the inhibitory rate of cell growth was detected by MTT assay, the apoptosis rate was determined by AO/EB assay, the apoptosis peak and the changes of cell cycle were measured by flow cytometry (FCM). Results Cell growth was significantly inhibited by sodium butyrate and the inhibitory effect was in time- and dose-dependent manner. The morphological changes of apoptosis in PC-3M cells were found. The cell cycle was arrested to G 1/G 0 and G 2/M, the number of cells in S phase reduced, sub-G 1 appeared. Conclusion Sodium butyrate can inhibit the cell growth and induce apoptosis in PC-3M.
【Fund】: 日本国际协力团资助项目 (第 5 9号 ) ;; 吉林省科技厅资助课题 (2 0 0 10 70 9)
【CateGory Index】: R737.25
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