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《Journal of Jilin University of (Medicine Edition)》 2005-02
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Effects of PQL on levels of immunal proteins, C3, C4 and expressions of CD4, CD8, and CD25 on lymphocytes of peripherial blood in patients with breast carcinoma undergoing radiotherapy

WANG Chun-gang~ 1,2, JIA Xiao-jing~ 1,3, DONG Li-hua~ 1,3, WU Zhen-feng~1, GONG Shou-liang~ 3, MA Xing-yuan~4, CHEN Yan-ping~4 (1. Department of Radiotherapy, Second Hospital, Jilin University, Changchun 130041,China; 2. Department of Radiotherapy, No.208 Hospital of PLA, Changchun 130062,China; 3. MH Radiobiolgy Reserch Unit,School of Public Health, Jilin University, Changchun 130021,China; 4. Department of Teaching Centre,School of Basic Medical Sciences, Jilin University, Changchun 130021,China)  
Objective To evaluate the effects of panaxatriol in quinquefolium leaf (PQL) on immune functions in the patients with breast carcinoma undergoing radiotherapy. Methods Thirty patients with breast carcinoma undergoing radiotherapy were randomly divided into 2 groups: panaxatriol treatment group (n=17) and control group (n=13). All patients in panaxatriol treatment group were administrated with PQL as well as radiotherapy, no administration in control group. After radiotherapy with 40 Gy, the white cells count and IgG, IgA, IgM, C3, and C4 values, and the percentages of CD4~+, CD8~+, CD25~+ and lymphocyte transformation rate of peripheral blood in the patients were examined. Results There were (4.02±0.67)×10~9·L~ -1 and (6.17±1.20)×10~9·L~ -1 white blood cells,respectively, in control and PQL groups. The lymphocyte transformation rate of peripheral blood were 7 966±1 562 in the control group, while 18 035±1 577 in PQL group, which was significantly higher than that in control group(P0.001). The percentages of CD8~+ and CD25~+ T lymphocytes in PQL group were significantly higher than those in control group (P0.05, P0.001). Conclusion The PQL could enhance the cellular immune function in patients with breast carcinoma undergoing radiotherapy.
【Fund】: 国家自然科学基金资助课题 (30 170 2 90 )
【CateGory Index】: R737.9
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