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《Journal of Jilin University of (Medicine Edition)》 2005-04
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Effects of wild ginseng fruit saponins on hemodynamics in isolated rat hearts

CHEN Yue~1, CAO Xia~2, LI Yong~3, YAN Wei-Qun~4 (1. Department of Pharmaceutical Analysis,School of Pharmacy,Jilin University,Changchun 130021,China;2. Department of Pharmacology,School of Pharmacy,Jillin University,Changchun 130021,China;3. Department of Epidemiology, School of Public Health,Jilin University,Changchun 130021,China;4. Department of Biochemistry,Institute of Frontier Medical Sciences,Jilin University,Changchun 130021,China)  
Objective To explore the effects of wild ginseng fruit saponins (WGFS) on hemodynamics in isolated rat hearts. Methods The isolated rat hearts were prepared and the effects of WGFS on HR, AP, LVSP, LVEDP, and ±dp/dtmax were observed. Results WGFS slowed HR and reduced AP, LVSP, and ±dp/dtmax (P0.05 or P0.01) in a dose-dependent manner. WGFS had no remarkable effect on LVEDP(P0.05). Conclusion WGFS has the effects of negative frequency named restraining cardiac muscle contraction and stretch function, and reducing rhythum of the heart and blood pressure.
【Fund】: 国家自然科学基金资助课题(30271222)
【CateGory Index】: R285
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