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《Journal of Jilin University of (Medicine Edition)》 2005-04
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Protective effects of Fosinopril on myocardial ischemia-reperfusion injury in rats

ZHAO Xue-zhong~1, ZHANG Zhi-guo~1,WANG Ye-ling~1, CAO Xia~2, YU Xiao-feng~2, XU Hua-li~2, QU Shao-chun~2,SUI Da-yuan~2(1. Department of Cardiovascular Medicine, First Hospital, Jilin University, Changchun 130021,China;2. Department of Pharmacology, School of Pharmacy,Jilin University,Changchun 130021,China)  
Objective To observe the protective effects of Fosinopril on myocardial ischemia-reperfusion injury in rats. Methods The myocardial ischemia-reperfusion model was induced by 30 min coronary occulusion and 24 h reperfusion in opened-chest anesthetized rats. The changes of aspartate aminotransferase(AST), lactate dehydrogenase(LDH), MB isoenzyme of creatine kinase(CK-MB), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, and malondialdehyde (MDA) content in serum were determined. Morphology of myocardial tissue was observed with optics and electron microscopes. Results Fosinopril decreased significantly the serum MDA content and AST, LDH and CK-MB activities as well as increased the serum SOD and GSH-Px activities. It also reduced edema and injury of ultrastructure in myocardial tissue. Conclusion Fosinopril has protective effects on myocardial ischemia-reperfusion injury, which may be related to scavenging the oxygen free radicals formed during reperfusion.
【Fund】: 吉林省科技厅资助课题(9905813)
【CateGory Index】: R96
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