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《Journal of Jilin University of (Medicine Edition)》 2005-05
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Experimental study on effects of Rhodosin and deer serum preparation on aging skin

HAO Li-ming,JIANG Wen-hua,DONG Zhi-yong,MENG Xiao-ting(Department of Histology and Embryology,Schoolof Basic Medical Sciences,Jilin University,Changchun 130021,China)  
Objective To study the effects of Rhodosin and deer serum preparation on aging skin.(Methods 12 guinea) pigs of 20 months with 3 cm×3 cm hair sheared from their backs were divided into control group and experimental group.Rhodosin and deer serum preparation was besmeared on the skin of guinea pigs in experimental group,and cosmetic matrix was besmeared on the skin of animals in control group for 60 d.The distribution of type Ⅲ collagen was observed with Sirius red staining and HE staining.The fission index of the cells of stratum basale,the thickness proportion of stratum corneum to epidermis,the volume density of the collagen fibers and small blood vessel in dermis,the number of fibroblasts in aging skin were meassured with technique of sterology.(Results Compared) with the control group,the distribution of type Ⅲ collagen in papillary layer,the fission index of the cells of stratum basale,the number of fibroblasts in papillary layer and the volume density of small blood vessel were increased in the experimental group(P0.01);the volume density of the collagen fibers in dermis and the thickness proportion of stratum corneum to epidermis were reduced in the experimental group(P0.01 or P0.05).Conclusion Rhodosin and deer serum preparation can defer the aging on skin.
【Key Words】: skin aging anti-aging drugs(TCD) Rhodosin and deerserum preparation
【Fund】: 吉林省科技厅项目资助课题(20001109)
【CateGory Index】: R285;
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