Association between MT2A gene polymorphism and type 2 diabetes mellitus

YANG Li-na~1,LI Hong-yan~1,LIU Ya-wen~2,SHI Jie-ping~2,LIU Qing~3,LI Dan-yang~1,QIAO Hui-zhen~2,LIU Ya~(1)(1.Department of Nutrition and Food Hygiene,School of Public Health,Jilin University,Changchun 130021,China;2.Department of Epidemiology,School of Public Health,Jilin University,Changchun 130021,China;3.Department of Endocrinology,First Hospital,Jilin University,Changchun 130021,China)  

Objective To investigate the genetic association of metallothionein(MT) 2A gene locus in chromosome 16 with susceptibility to type 2 diabetes mellitus(T2DM) in Chinese Han people.Methods The techniques of PCR and restriction fragment polymorphism(RFLP)were used to examine single nucleotide polymorphism(SNP)of MT2A gene in 129 patients with T2DM(case group) and 115 unrelated healthy individuals(control group).Results The distributions of genotype frequencies of rs10636 were not deviated from the Hardy-Weinberg equilibrium;there were no remarkable differences of the frequency distributions of GG,GC and CC of MT2A between cases and controls(χ~2=0.202,P0.05),and the frequency distributions of G and C had no markedly differences between cases and controls(χ~2=0.136,P0.05).Conclusion The rs10636 of MT2A gene may not be associated with T2DM.

【Key Words】： diabetes mellitus non-insulin-dependent metallothionein rs10636
【Fund】： 国家自然科学基金资助课题(30370669)
【CateGory Index】： R587.1
【DOI】： cnki:ISSN:1671-587X.0.2005-05-037

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