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《Journal of Jilin University of (Medicine Edition)》 2005-06
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Action of lowering blood sugar levels of corn active polysaccharide on diabetic mice

ZHANG Yan-rong,CHEN Li-na,WANG Da-wei~(College of Food Engineering,Jilin Agricultural University,Changchun 130118,China)  
Objective To study the action of corn active polysaccharide(CAP) on blood sugar levels in diabetic mice.Methods Fifty mice were randomly divided into control group,alloxan model group,CAP 3.50,1.75,0.88 g·kg~(-1) groups(n=10). Mice in each group were exhibited with CAP once a day for 15 d,on the sixth day,mice in every group were injected with alloxan physiological salt solution 80 mg·kg~(-1) in caudal vena except control group,mice in control group were injected with physiological salt solution at the same volume.16 h before the last exhibition,mice in every group were starved.1 h before the last exhibition,blood was extracted in eyeballs,sera were separated and the contents of blood sugar were determined by auto-biochemistry analyzer,mice were killed at once.The liver samples were obtained and the contents of liver glycogen were determined.Another 60 mice were divided into 5 groups with the method mentioned above.Each group was exhibited once a day for 10 d continuously.1 h after the last exhibition,except control group,the mice were injected with adrenalin hydrochloride(250 μg·kg~(-1)) through abdominal cavity,after 30 min,blood was extracted by decapitation,and the contents of blood sugar and liver glycogen were determined by auto-biochemistry analyzer.Results CAP 3.50 g·kg~(-1) had obvious inhibitory effect on the raise of blood sugar in diabetic mice(model group)(P0.05),it had obvious action on reducing the contents of liver glycogen in diabetes mice(model group)(P0.05),and 3.50 g·kg~(-1) was superior to 1.75 g·kg~(-1).CAP with different doses had obvious actions on inhibiting the raise of blood sugar in adrenine mice(model group)(P0.001,P0.01,P0.05),and had obvious action on increasing the reduction of liver glycogen on adrenine mice(model group),and 3.50 g·kg~(-1) was superior to 1.75 g·kg~(-1).(Conclusion CAP has) the function of lowering blood sugar levels in alloxan diabetic mice and hyperglycemia mice induced by adrenine.
【Fund】: 国家“十五”重大科技攻关专项(2001BA501A01)
【CateGory Index】: R587.1
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