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《Journal of Jilin University(Medicine Edition)》 2006-01
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Expression of peroxisome proliferator activated receptor γ in atherosclerosis in rabbits

QIN Ling, LEI Yu, ZHANG Wei-hua, CHEN Ai-jun, HUANG Ke-xin, LIU Li-hui ( Department of Cardiology, First Hospital, Jilin Univesity, Changchun 130021, China; Department of Histology and Embryology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China)  
Objective To investigate the expression of peroxisome proliferator activated receptor γ (PPARγ) in atherosclerosis. Methods 16 rabbits were randomly divided into cholesterol diet group and normal diet group (control group) (n = 8). Atherosclerosis models were built in cholesterol diet group. Serum TC, TG, LDL in rabbits were measured after bred for 0 , 8 and 16 weeks in two groups. After 16 weeks the aortas were harvested for histomorphometry observation and PPARγ immunohistochemistry analysis. Results The differences of TC, TG and LDL levels between two groups were not significant in 0 week (P0. 05); and after 8 and 16 weeks, compared with 0 week and control group, serum TC, TG, LDL levels in cholesterol diet group were significantly increased (P0. 01). The aortas intima plaques were formed in cholesterol diet group by the aorta histomorphometry observation, plaque/intima size in cholesterol diet group and control group (P/I) were (28. 12±3. 77)% and 0, respectively (P0.01), intima thickness were (67. 47±7. 13) μm and (4. 45±0. 58) μm (P0. 01), intima/ medium thickness (I/M) were 0. 878 ± 0. 370 and 0. 054 ± 0. 007 (P0.01). With SP method and DAB dye, PPARγ expressions in cholesterol diet group and control group were (14. 38 ± 2. 58)% and (7. 82 ± 0. 96) %, respectively (P0. 01). Conclusion PPARγ can express excessively in atherosclerosis location, it may involve in the process of atherosclerosis.
【Fund】: 吉林省科技厅资助课题(20050408—3)
【CateGory Index】: R543.5
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