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《Journal of Jilin University(Medicine Edition)》 2006-01
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Ameliorative effects of pseudoginsenoside GQ on isoproterenol-induced acute myocardial ischemia in rats

LIU Jin-ping, ZHAO Chun-fang, LI Ping-ya , LI Xian ( Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang 110015, China; Department of New Drug, Institute of Froniter Medical Sciences, Jilin University, Changchun 130021, China; Department of Pharmaceutical analysis, Jilin University, Changchun 130021, China)  
Objective To study the ameliorative effects of pseudoginsenoside GQ (PGQ) on electrocardiogram changes in rats with acute myocardial ischemia induced by isoproterenol (ISO). Methods 50 Wistar rats were divided into five groups (n=10) randomly. Group I : i. v. 0.9% sodium chloride water liquor; Group II : i. v. verapamil hydrochloride of 0. 2 mg · kg-1 ; Group III : i. v. 3. 0 mg · kg-1 of PGQ; Group IV : i. v. 6. 0 mg · kg-1 of PGQ; Group V : i. v. 12. 0 mg · kg-1 of PGQ. Myocardial ischemia was induced by intravenous injection of ISO (2.0 mg · kg-1). ST-segment changes in the lead II , precordial in lead V1 and precordial in lead V2 were examined. Results In lead II , lead precordial V 1 and lead precordial V 2 , ST-segment elevation of three PGQ groups were not obvious at every time point, the extents of ST-segment elevation were lower than those in sodium chloride water liquor group (P0. 05, P0. 01, P0. 001). Conclusion PGQ has the ameliorative effects on electrocardiogram changes in rats with ISO-induced acute myocardial ischemia.
【Fund】: 吉林省科技厅科技发展重大项目资助课题(20011109—5)
【CateGory Index】: R285.5
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