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《Journal of Jilin University(Medicine Edition)》 2006-03
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Genetic toxicity of Agrimonia Pilosa Ledeb in male mouse genital cells

PANG Hui-min~1,ZHU Yu-zhuo~(1*),QIAO Ping~2,WEN De-zhong~1(1.Department of Medical Genetics,School of Basic Medical Sciences,Jilin University,Changchun 130021,China;2.Department of Pharmacology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China)  
Objective To examine the genetic toxicity of Agrimonia Pilosa Ledeb on male mouse reproductive cells.Methods Sperm abnormality test,sister chromatid exchange(SCE) test in mouse spermatogonia and unscheduled DNA synthesis(UDS) test in mouse sperms were used.Thirty mice were divided into six groups((5 mice) per group): negative control(NS),Mitomycin C(MMC) or methyl methyl sulfonate(MMS) group,and Agrimonia Pilosa Ledeb groups(1.0,2.0,4.0 and 8.0 g·kg~(-1)).Results Sperm abnormality or SCE had no significant differences between test groups and control group(P0.05),indicating that Agrimonia Pilosa Ledeb could not induce any UDS in mouse sperms.Conclusion Agrimonia Pilosa Ledeb has no genetic toxicity in male mouse reproductive cells at the range of doses that are applied under the experimental conditions.
【Fund】: 吉林省科技厅科技发展计划项目资助课题(20010529)
【CateGory Index】: R285
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