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《Journal of Jilin University(Medicine Edition)》 2006-04
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Effects of methylmercury on outward potassium currents in isolated outer hair cells of guinea pig cochlea

LIU Shu-fang~1,GUO Xiao-feng~(1),QUAN Cheng-shi~2(1.Department of Otorhinolaryngology and Head-Neck Surgery, First Hospital,Jilin University,Changchun 130021,China;2.Department of Pathology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China)  
Objective To investigate the effects of methylmercury on outward potassium currents in isolated outer hair cells of guinea pig cochlea.Methods The whole-cell patch clamp technique was used.Calcium sensitive outword potassium currents were recorded when the concentrations of mercurial were 1/1000 LD_(50),1/100 LD_(50) and 1/10 LD_(50).Results After methylmercury poisoning,amplitudes of the outword potassium currents I_(K(Ca)) were(1.48±0.28),(1.36±0.16) and(1.22±0.13)nA.Compared with control group,the amplitudes in three methylmercury poisoning groups were decreased by 8%,16% and 25%(P0.05).Conclusion Methylmercury can reduce I_(K(Ca)) in a dose-dependent manner,it may be one of the mechanisms of ototoxicity.
【Fund】: 吉林省科技厅资助课题(990590)
【CateGory Index】: R764
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