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《Journal of Jilin University(Medicine Edition)》 2006-04
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Effects of methylmercury on outward potassium currents in isolated outer hair cells of guinea pig cochlea

LIU Shu-fang~1,GUO Xiao-feng~(1),QUAN Cheng-shi~2(1.Department of Otorhinolaryngology and Head-Neck Surgery, First Hospital,Jilin University,Changchun 130021,China;2.Department of Pathology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China)  
Objective To investigate the effects of methylmercury on outward potassium currents in isolated outer hair cells of guinea pig cochlea.Methods The whole-cell patch clamp technique was used.Calcium sensitive outword potassium currents were recorded when the concentrations of mercurial were 1/1000 LD_(50),1/100 LD_(50) and 1/10 LD_(50).Results After methylmercury poisoning,amplitudes of the outword potassium currents I_(K(Ca)) were(1.48±0.28),(1.36±0.16) and(1.22±0.13)nA.Compared with control group,the amplitudes in three methylmercury poisoning groups were decreased by 8%,16% and 25%(P0.05).Conclusion Methylmercury can reduce I_(K(Ca)) in a dose-dependent manner,it may be one of the mechanisms of ototoxicity.
【Fund】: 吉林省科技厅资助课题(990590)
【CateGory Index】: R764
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 GE Jing-yan, ZHAO Chun-yan, ZHANG Wen-jie, ZHAO Ming, SUN Ya-qin, ZHONG Guo-gan  (Department of Physiology,School of Basic Medical Sciences,Jilin University,Changchun 130021, China);Effects of sphingosine-1-phosphate on calcium current in isolated ventricular myocytes of guinea pig[J];Journal of Jilin University of (Medicine Edition);2005-01
2 YANG Jun 1 WANG Jibao 2 ( 1 Department of Otorhinolaryngology Head and Neck Surgery, Renji Hospital Affiliated Shanghai Second University, Shanghai 200001; 2 Department of Otorhinolaryngology, the Union Hospital, Tongji Medical College, Huazho;Outwardly rectifying potassium currents in isolated outer hair cells in cochlea of guinea pig[J];Journal of Clinical Otorhinolaryngology;2002-01
3 Cui Guiying, Tang Hao, Li Yuxing, Wu Yuhuan, Zhang He, Zhang Xiaofang (Department of Physiology, College of Basic Medical Sciences, China Medical University, Shenyang,110001);Effects of Streptomycin on Calcium-Sensitive Outward Potassium Currents in Isolated Outer Hair Cells of Guinea Pig Cochlea[J];Journal of China Medical University;2000-06
4 CHANG Qing ,GONG Shu-sheng,DING Juan, TANG Ming, Jürgen Hescheler De partment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhon g University of Science and Technology,Wuhan 430022,China;Effect of linopirdine on potassium currents in isolated outer hair cells and Dei ters′ cells of the cochlea from guinea pig[J];Chinese Journal of Otorhinolaryngology;2003-04
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 ZHANG Wen-jie,GE Jing-yan,ZHAO Chun-yan,ZHANG Xue-xin,ZHAN Shu,ZHONG Guo-gan~*(Department of Physiology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Effects of exogenous phosphatidic acid on calcium current of ventricular myocytes[J];Journal of Jilin University(Medicine Edition);2006-03
2 GE Jing-yan1,ZHANG Wen-jie1,CHEN Xia2,SUN Xiao-xia3,ZHAO Ming1,ZHAO Chun-yan1,ZHONG Guo-gan1(1.Dept.of Physiology;2.Dept.of Pharmacology;3.Research Center of Functional Experimental Sciences,School of Basic Medical Sciences,Jilin University,Changchun130021,China);Sphingosine 1-phosphate prolongs action potential duration and inhibits voltage-dependent potassium current in guinea-pig ventricular myocytes[J];Basic & Clinical Medicine;2008-01
3 KANG Xixun1 KONG Weijia1 LI Wanrong2 ZENG Xiaorong3YANG Yan3 ZHANG Song1 GUO Changkai1(1Department of Otolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan,430022,China;2Department of Otolaryngology-Head and Neck Surgery, Luzhou Medical College Affiliated Hospital; 3Institute of Myocardium Electrophysiology, Luzhou Medical College);A simple method of separating outer hair cells in guinea pig[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2008-18
4 CUI Gui-ying, TANG Hao, WU Yu-huan(Department of Physiology, China Medical University, Shenyang 110001, China);Changes of K~+ channels of outer hair cells in guinea pig cochlea with streptomycin ototoxicity[J];Chinese Journal of Pathophysiology;2002-06
5 SUN De-fa1a,WANG Jian-hua1b,XU Xiu-rong1a,ZHANG Zhi-min2,CAO Da-jiang1a (1 a College of Animal Science;b College of Veterinary Medicime,Northwest A&F University,Yangling,Shaanxi 712100,China;2 Liaoning Dalian Jinzhou Rare Fur Animal Feeding Company,Dalian,Liaoning 116100,China);Histopathological study on nervous system in self-injurious mink[J];Journal of Northwest A & F University(Natural Science Edition);2010-09
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Hong-yu 1 ,MENG Xiang-yu 2 (1.Shenzhen Center for Disease Prevention and Control, Shenzhen518020,Guangdong,China;2.Pulandian Center for Disease Prevention and Control,Pulandian116200,Liaoning,China);Effects of Methyl Mercury Chloride on Transcription Activities of Brain Chromatin from Rats in Various Stages of Development[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-03
2 ZHANG Jian-peng 1 ,REN Xu-yi 1 ,GUO Ting-ting 2 , FENG Wei-hua 1, ,JIAO Bing-hua 1, (1.Department of Biochemistry and Molecular Biology,Second Military Medical University,Shanghai200433,China; 2.Life Science and Technology College,Shanghai Fishery University,Shanghai200090,China);cDNA Microarray Analysis in Testes of Rats Exposed to Low Cadmium Toxicity[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-02
3 HUANG Qiu-chan et al(Department of Chemistry and Life Science,Nanning Teachers College,Longzhou,Guangxi 532400);Review on the Toxicological Effect and the Mechanism of Cadmium to Human Health[J];Journal of Anhui Agricultural Sciences;2007-09
4 Wei Youhuan,Huang Qiuchan,Su Xiufang(Department of Chemistry and Biology Engineering,Nanning Teachers College,Longzhou 532400,China);Review on the Toxicological Effect and the Mechanism of Nickel to the Human Health[J];Environmental Science and Management;2008-09
5 GUO Jie 1,Dong Li bo 2,ZHANG Chun xia 1, LI Zhi chao 1 (1. Dept.of Toxicology,School of Public Health,Jilin University, Changchun 130021,China; 2. Institute of Environmental Health Monitoring Chinese Acadamy of Preventive Medicine);The effect of methylmercury chloride on DNA binding activities of transcription factor, cAMP responsible element binding protein, of nuclearprotein extracts from cerebella of developing rats[J];Journal of Norman Bethune University of Medical Science;2002-04
6 JIN Ming hua 1,SHI Long 1,SUN Zhi wei 1 ,HU Ying 1,LIU Xiao mei 1,SONG Jun xue 2,LIU Ni 2 (1. Dept.of Hygienic Chemistry, School of Public Health, Jilin University, Changchun 130021, China;2.Dept.of Cadre, The First Hospital,Jinlin Unive;The effect of methyl mercury on the cell cycles of germ cells in the mouse testis[J];Journal of Norman Bethune University of Medical Science;2002-05
7 JIN Ming-hua~1, ZHANG Jing~2, LIU Xiao-mei~1, WANG Wen~1, ZHANG Jie~1, SHI Long~1, SUN Zhi-wei~1 (1. Department of Hygienic Chemistry, School of Public Health, Jilin University, Changchun 130021, China;2. Department of Epidemiology, Medical College,Beihua University, Jilin 132001, China);Reproductive and developmental toxicities of male mice induced by methylmercury[J];Journal of Jilin University of (Medicine Edition);2005-04
8 GUO Jie~1,BI Xiao-ying~1,LEI Cui-ping~2,LI Yong-jin~1,LI Zhi-chao~(1*)(1.Department of Health Toxicology,School of Public Health, Changchun 130021,China;2.Institute of Radiation Safety,Chinese Center of Disease Prevention and Control,Beijing 100088,China);Effects of chronic mthylmercury chloride exposure on activity of protein kinase C in rat cerebellum during development[J];Journal of Jilin University(Medicine Edition);2006-03
9 FANG Min, WANG Xiao Dong (Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA);The mitochondrial pathways of apoptosis[J];Journal of Beijing Medical University;2002-01
10 MA Da-Long △ (Peking University Center for Human Disease Genomics, Beijing 100083,China);Discovery and functional clarification of novel human genes encoding cytokines a nd apoptosis-related molecules[J];Journal of Beijing Medical University;2002-05
【Secondary References】
Chinese Journal Full-text Database 6 Hits
1 JING You-ling,WANG Yan-lei,GENG Fei, SUN Na,WANG Xiao-jun,YIN Dan-dan (North China Coal Medical College,Tangshan 063000 China);Experimental Research of Relation between Acute Mercury Poisoning and Oxidative Stress[J];Industrial Health and Occupational Diseases;2010-04
2 LIU Hong-liang, ZENG Qiang,ZHAO Liang.Tianjin Centers for Diseases Control and Prevention,Tianjin 300011,China.;Research Advance in Relationship between Hemodialysis Water and Human Health[J];Journal of Environment and Health;2009-02
3 XUE Chang-jiang,HAO Feng-tong,WU Na,LI Hui-ling(Department of Occupational Diseases and Toxication,Chaoyang Hospital Affiliated to the Capital University of Medical Science,Beijing 100020,China);Analysis of Clinical Characteristics on Non-occupational Mercury Poisoning Caused by Different Reasons[J];Journal of Environmental & Occupational Medicine;2011-02
4 XUE Chang-jiang,WANG Di-xin,ZHAO Jin-yuan(Department of Occupational Diseases and Poisoning,Chaoyang Hospital affiliated to the Capital University of Medical Science,Beijing 100020,China);Etiology and clinical features of toxic nephropathy[J];Chinese Journal of Industrial Medicine;2011-02
5 LI Hai,WANG Jin-hua,LI Biao,et al.Department of Histology and Embryology Youjiang Medical College for Nationalities,Baise 533000;The effects of treatment in Haierfu syrup on genital gland of mice exposed to mercury[J];Chinese Medical Journal of Metallurgical Industry;2010-04
6 JING You-ling1, WANG Yan-lei1, YIN Dan-dan1, CAO Bo-hai2, ZHANG Wei1, GENG Fei1, SUN Na1(1. Department of Physiology, North Coal Medical College, Tangshan 063000; 2. Xie He Yi Yuan, Tangshan 063000, China);Protective effects and pathogenesis of complex salvin miltiorrhiza on acute mercury poisoning in rabbits[J];Chinese Journal of Applied Physiology;2010-03
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 LI Ying ji, CHEN Xia, GE Jing yan, YAN Li,ZHANG Wen jie, ZHONG Guo gan (Dept. of Physiology, School of Basic Medical Science, Jilin University, Changchun 130021,China);Effect of Lysophosphatidic Acid on Calcium Current in Isolated Ventricular Cells of Guinea Pig[J];Journal of Norman Bethune University of Medical Science;2003-01
2 YANG Jun,WANG Jibao.Department of Otorhinolaryngology, Union Hospital of Tongji Medical University, Wuhan 430022,China Corresponding author: YANG Jun(Email:yangjun67@263.net);Outward potassium currents in isolated Deiters′ cells of guinea pig cochlea[J];Chinese Journal of Otorhinolaryngology;2000-03
3 Yang Jun *,Wang Jibao, Wei Shunhui. *Union Hospital,Tongji Medical University,Wuhan 430022;Effects of neuroactive substances on intracellular free Ca 2+ concentration in isolated outer hair cells of the guinea pig cochlea[J];CHINESE JOURNAL OF OTORHINOLARYNGOLOGY;1998-05
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