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《Journal of Jilin University(Medicine Edition)》 2006-06
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Effect of Acanthopanax senticosus saponins on organ blood flow in anesthetized dogs

LI Yang,QU Shao-chun,YU Xiao-feng,XU Hua-li,SUI Da-yuan~*(Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China)  
Objective To study the effect of Acanthopanax senticosus saponins (ASS) on organ blood flow and vascular resistance in anesthetized dogs.Methods The cerebral blood flow(CBF),cerebral vascular resistance(CVR),peripheral blood flow(PBF),peripheral vascular resistance(PVR),blood pressure(SDP and DBP) and heart rate(HR) were measured using the MF-27 electromagnetic flowmeter.Results ASS(15 and 30 mg·kg~(-1) iv perfusion for 60 min) augmented CBF and PBF,decreased CVR and PVR within 180 min and slowed down HR at 60-180 min.In addition,ASS(30 mg·kg~(-1) iv perfusion for 60 min) could obviously reduce SBP and DBP.Conclusion Protective effect of ASS on experimental cerebral ischemia may be related to improving cerebral circulation and increasing cerebral blood supplyment.
【Fund】: 吉林省科技厅资助课题(19890310-05);; 吉林省中医管理局科研基金重点课题(98A17)
【CateGory Index】: R285
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