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《Journal of Jilin University(Medicine Edition)》 2007-02
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Inhibitory effects and immunoregulation of Juglans mandshurica maxim extract on S_(180) mouse sarcoma

GUO Jian-hua1,CUI Li-ming1,LI Shu-hong1,LIU Li1,HE Rong-hua1,LIU Bing2(1.Department of Pathogenobiology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China;2.Department of Medical Genetics,School of Basic Medical Sciences,Jilin University,Changchun 130021,China)  
Objective To discuss the inhibitory effects of Juglans mandshurica maxim extract(JMME) on S180 mouse sarcoma and its immunity accommodation.Methods The mice bearing sarcoma in three groups(n=10)were aderminastered with JMME with doses of 0.023,0.045 and 0.090 g·kg-1·d-1by gavage.Positive and negative control groups were set up.The inhibitory rate of JMME on S180 mouse sarcoma was detected.The cell culture was used to observe the inhibitory effect of JMME on the sarcoma,the influences of JMME on the tumor necrosis factor(TNF) activity and the interleukin-2(IL-2) luring level were observed with MTT.Results JMME had inhibitory effect on the sarcoma.The inhibitory rates in JMME groups with different does were 32%,43%,56%,respectively,there were significant differences compared with negative group(P0.05).The inhibitory rate of JMME on tumor cell cultivated in vitro(60.10%)was higher than that in control group(P0.05).The TNF activity and IL-2 luring level in JMME group were higher than those in control group(P0.05).Conclusion JMME has significantly inhibitory effect on S180 mouse sarcoma.Its mechanism is associated with inhibition of the growth of the exosomatic tumor and regulation of immunity function of the body.
【Fund】: 吉林省科技厅资助课题(200505187);; 吉林省卫生厅资助课题(20060978)
【CateGory Index】: R285.5
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