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《Journal of Jilin University(Medicine Edition)》 2007-05
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Protective effects of Ginsenoside-Rb on experimental myocardial ischemia-reperfusion injury in rats

QU Shao-chun1,SUI Cheng1,2,YU Xiao-feng1,WANG Xuan-hui1,HE Xiao-xi,XU Hua-li1(1.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China;2.Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University,Nanjing 210038,China)  
Objective To observe the protective effects of Ginsenoside-Rb(G-Rb)on experimental myocardial ischemia-reperfusion injury in rats.Methods The myocardial ischemia-reperfusion model was induced by 30 min left anterior descending coronary occulusion and 24 h reperfusion in openchest anesthetized rat.The changes of aspartate aminotransferase(AST),lactate dehydrogenase(LDH),MB isoenzyme of creatine kinase(CK-MB),superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)activities and malondialdehyde(MDA)content in serum,and prostacycline(PGI2)and thromboxane A2(TXA2)levels in plasma were determined.At the same time,the activity of platelet aggregation was also determined.Results In rats treated with G-Rb(with dose of 50 and 100 mg·kg-1 i.g for 7 d),the MIS was significantly reduced(P0.05 or P0.01),the AST,LDH and CK-MB activities in serum and the TXA2 level in plasma were declined(P0.05 or P0.01),while PGI2 level in plasma and PGI2/TXA2 ratio were increased signficatly(P0.05 or P0.01).In addition,the LPO content in serum was declined,SOD and GSH-Px activities in serum were increased markedly(P0.05 or P0.01).The platelet aggregation rate(PAR)at 1,3 and 5 min and maximum platelet aggregation rate(MOAR)were decreased markedly(P0.05 or P0.01).Conclusion G-Rb has protective effects on myocardial ischemia-reperfusion injury through improving free radicals metabolism,decreasing TXA2 level in plasma,increasing PGI2 level in plasma and PGI2/TXA2 ratio,and inhibitting the activity of platelet aggregation etc.
【Fund】: 吉林省科技厅新药基金项目资助课题(20000329)
【CateGory Index】: R285.5
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