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《Journal of Jilin University(Medicine Edition)》 2008-04
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Effects of Qianlie Shutong Tablets on inflammatory reaction of nonbacterial prostatitis in rats

LIN Tian-mu1,GUAN Qing-xiang2,LI Hong3,YANG Shi-jie3,WANG En-si1,2(1. Department of Biology Pharmacy,School of Life Science,Jilin University,Changchun 130012,China;2. Department of Natural Pharmaceutical Chemistry,School of Pharmacy,Jilin University,Changchun 130021,China;3. Department of Pharmacology,School of Basic Medical Sciences,Changchun 130021,China; )  
Objective To investigate the effects of Qianlie Shutong Tablets(QLS) on inflammatory reaction of nonbacterial acute and chronic prostatitis in rats and provide medical basis for its clinical use. Methods A total of 60 male rats were randomly assigned into normal group,model group,drug control group (Qianliekang group),low -dose(17.5 mg·kg-1),mid-dose (35.0 mg·kg-1) and high -dose QLS (70.0 mg·kg-1) groups,10 rats in each group. White cell count,lecithin corpuscle density in prostatic fluid,prostate weight and prostate index were observed respectively after acute rat models were made by injecting 1 % carrageenan in the seminal vesicle of prostate gland notopodium. The chronic prostatitis models were made by injecting hemorrhoid into prostate gland. The morphological changes of prostate tissue were observed 30 d after administration. Results Compared with model group,white cells in prostate fluid were obviously decreased (P0.05) and lecithin corpuscle densities were obviously increased (P0.05 or P0.01) in 35.0 and 70.0 mg·kg-1 QLS groups. However,QLS with the dose of 17.5 mg·kg-1 did not obviously affect the number of white cells and lecithin corpuscle density. Compared with model group,QLS with the dose of 70.0 mg·kg-1 significantly diminished prostate weight(P0.05)and prostate index(P0.01),as well as significantly inhibited infiltration of white cells(P0.01)and fibroblast accrementition (P0.05),which was similar with the positive Qianliekang group. QLS with the dose of 35.0 mg·kg-1 significantly diminished prostate index(P0.05) and inhibited infiltration of white cells(P0.01). Conclusion QLS has inhibitory effects on inflammatory reaction of nonbacterial acute and chronic prostatitis.
【Fund】: 吉林省科技厅科技发展计划项目基金资助课题(20020503-11)
【CateGory Index】: R285
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