Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Jilin University(Medicine Edition)》 2009-03
Add to Favorite Get Latest Update

Effects of sphingosine-1-phosphate on single-aisle delayed rectifier K+ current in heart ventricular myocytes of guinea pigs

ZHANG Wen-jie,XUAN Li-ying,HE Yong-feng,CAO Yu-feng,ZHAO Chun-yan,TAN Wen-jia*(Department of Physiology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China)  
Objective To investigate the effects of sphingosine-1-phosphate(S1P) on single-aisle delayed rectifier K+ current in heart ventricular myocytes of guinea pigs and explore the role of S1P in ventricular arrhythmia.Methods The Langendorff perfusion method was used to isolate ventricular myocytes of guinea pigs and the ventricular myocytes were randomly divided into normal control group,S1P(2.2 μmol·L-1) group and S1P(2.2 μmol·L-1)+Suramin(200 μmol·L-1)group.The current of delayed rectifier potassium channel was recorded by cell-attached recording.Results Compared with normal control group by cell-attached recording and respecting the channel dynamics,the opening dwell time and the opening probability decreased,while the closing dwell time increased in S1P group(P0.05);and there was no obviously difference between S1P+Suramin group and normal control group while respecting the channel dynamics(P0.05).Conclusion S1P inhibits delayed rectifier potassium current of ventricular myocytes of guinea pigs by shortening its opening dwell time,extending its closing dwell time and reducing the opening probability.And the functions above are mediated by membrane receptor.
【Fund】: 吉林省科技厅科研基金资助课题(200705367)
【CateGory Index】: Q46
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 LAN Tonghan, YUAN Huijun, LIN Jiarui. College of Life Sciences and Techology,Huazhong University of Science and Technology, Institute of Biomedical Engineering, Wuhan 430074;A Single Delayed Rectifier K~+ Channels in Rat Dorsal Root Ganglion Neurons[J];Beijing Biomedical Engineering;2004-02
2 WANG Tao1), QIN zhiping2) 1)Department of Cadre ward, the second Affiliated Hospital,Zhengzhou University, Zhengzhou 450014 2)Department of Cardiology,the second Affiliated Hospital,Zhengzhou University, Zhengzhou 450014;Effect of perindopril on oxidative stress and myocyte apoptosis after myocardial infarction in rats[J];Journal of Zhengzhou University(Medical Sciences);2008-02
3 ZHAO Ming,ZHAO Chun-yan,ZHANG Wen-jie,et al.;The effects of sphingosine-1 1-phosphate(SIP) on the action potential and contractile in guinea pig ventricular myocardium[J];Chinese Journal of Applied Physiology;2007-01
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 ZHAO Ming1 ZHANG Wenjie2 ZHAO Chunyan2(1Department of Cardiology, Affiliated Hospital of Inner Mongolia Nation University, Tongliao, 028000, China; 2Department of Physiology, Preclinical Medical College, Jiling University);Effects of sphing-1-phosphate on the two delayed rectifier potassium currents of the ventricular myocytes[J];Journal of Clinical Cardiology;2008-09
2 ZHANG Song-yu,DU Yi-Mei,CHENG Long-xian,HUANG Gang,LIU Li-li,LIAO Yu-hua(The affiliated Union Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,P.R.China);Effects of FTY720 on action potential and contraction force of human atria fibers[J];Shandong Medical Journal;2008-29
3 ZHANG Liping, SU Jianhua,CHEN Yufang, TANG Jinrong, XIAO Hang Department of Neurology, The People's Hospital of Jintan, Jintan 213200, China;Protective Effect of Methycobal on the Neuron of Damaged Sciatic Nerve in Rats[J];Tianjin Medical Journal;2008-08
4 ZHAO Ming~1,ZHANG Wen-jie~2,ZHAO Chun-yan~2 (1.Department of Cardiology,Affiliated Hospital of Innemongol Nation University,Tongliao 028000; 2.Department of Physiology,Basic Medical Faculty of Jilin University,Changchun 130021);THE EFFECTS OF SPHING-1-PHOSPHATE(S1P)ON THE POTASSIUM CHANNEL OF THE VENTRICULAR MYOCYTES[J];Chinese Journal of Applied Physiology;2009-01
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Tong Zhengqing,Zou Fei,Gao Tianming Department of physiology;A single delayed rectifier K+ channels in rat striatal neurons[J];ACAD J ISI MED COLL PLA;1994-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved