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《Journal of Jilin University(Medicine Edition)》 2010-05
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Protective effects of total flavonoids of Bidens bipinnata L. on acute and chronic liver injury induced by carbon tetrachloride in mice

LI Hong,GUAN Feng-ying,LI Lan-lan,YANG Shi-jie (Department of Pharmacology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China)  
Objective To investigate the protective effects of total flavonoids of Bidens bipinnata L.(TFB)on acute and chronic liver injury in mice induced by carbon tetrachloride and mechanisms.Methods Sixty Wistar rats were randomly divided into control group,model group,Hu-Gan-Pian (4g·kg-1)group and TFB (120,60,30mg·kg-1)groups.The acute and chronic liver injury model in mice were induced by different dosages and administration times of carbon tetrachloride respectively to study the effects of TFB on liver index,hepatic morphological changes and detect the contents of SOD,MDA,ALT and AST in serum.Results Compared with model group,the degree of hepatic edema in TFB (120,60,30mg·kg-1)and Hu-Gan-Pian (4g·kg-1) groups were decreased (P0.05or P0.01),the contents of AST,ALT and MDA in serum were decreased (P0.05or P0.01),and the contents of SOD were increased (P0.05or P0.01).TFB and Hu-Gan-Pian could ameliorate the pathological lesion.Conclusion TFB has protective effects on carbon tetrachloride-induced acute and chronic liver injury in mice,which may be related to inhibition of lipid oxidation.
【Fund】: 吉林省科技厅科研基金资助课题(200705366)
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 9 Hits
1 Qian Yuecheng,Zhang Weizhong,Zhou Huaifa,et al Shanghai Municipal Hypertension Institute,Ruijin Hospital Affiliated to Shanghai Second Medical University(200025);Clinical Research on Beggarticks to Blood Pressure[J];Journal of Zhejiang College of Tcm;2003-01
2 ZHANG Xin-mu1,HE Jin-chao1,YANG Li-li1,2,ZHANG Ying-yu1,DONG Wen3,HOU Li-zhong1,YAN Wei-qun1(1.Department of Biochemistry,Institute of Frontier Medical Sciences,Jilin University,Changchun 130021,China;2.Deparment of Immunology,Tianjin Cancer Hospital and Institute,Tianjin Medical University,Tianjin 300060,China;3.Hongqiao Hospital of Tianjin,Tianjin 300130,China);Hepatoprotective effects of rhKD/APP on acute hepatic injury[J];Journal of Jilin University(Medicine Edition);2007-01
3 BAI Zhen-zi1,JIANG Yan-fang2,TONG Li-fang1,CHENG Wei1,ZHAO Hong-yu1,NIU Jun-qi2(1. Department of Infectious Disease,Chinese-Japan United Hospital,Jilin University,Changchun 130033,China;2. Department of Infectious Disease,First Hospital,Jilin University,Changchun 130021,China);Effects of Jiangzhitong on carbon tetrachloride-induced chronic liver injury in rats[J];Journal of Jilin University(Medicine Edition);2009-02
4 TANG Gui-fang,PANG Hui,YU Yan-hong(Dept of Hepatitis Diseases,Guangxi Nanxishan Hospital,Guilin 541002,China);Preventive effect of extraction from Bidens pilosa L on experimental liver injury in mice[J];Journal of Shanxi Medical University;2006-09
5 HU Wei1,CHEN Fei-hu1,WU Fang-rong1,WANG De-qun2,HE Xiao-li2(1.School of Pharmacology,Anhui Medical University,Hefei 230032,China;2.School of Pharmacology,Anhui Traditional Chinese Medical College,Hefei 230038,China);Pharmacognosy Identification of Bidens bipinnata L.[J];Lishizhen Medicine and Materia Medica Research;2009-02
6 JIANG Tao~1*,QIN Lu-ping~2,ZHENG Han-chen~2,LUAN Long~1,HAN Ting~2 (1.Shanghai Nabio Biotechnology Company,LTD,Shanghai 201203,China;2.Department of Pharmacogonosy,College of Pharmacy,Second Military Medical University,Shanghai 200433,China);Studies on the Flavonoids and Antilipid Peroxidantion of Bidens bipinnata[J];Natural Product Research and Development;2006-05
7 Zhou Bei(School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang Liaoning 110016,China);Studing the Relive Pain Function of Bidens Bipinnata L.[J];Modern Chinese Medicine;2007-02
8 HUANG Chuan-feng,MA Yu-hong,ZHOU Xin,et al.Zhongnan Hospital of Wuhan University,Wuhan,Hubei 430061,China;Effects of The Different Extracts of Bidens Bipinnata L.on Blood Lipids,NO and NOS in Experimental Hyperlipidemia Rats[J];Chinese Journal of Modern Drug Application;2009-17
9 LI Jing1,WU Yunxia2,WANG Jing2 1Department of Emergency,Hubei General Hospital of Chinese People's Armed Police Forces,Wuhan 4300602Hubei Key Laboratory of Natural Pharmacochemistry and Resources Evaluation,Department of TraditionalChinese Herbs,Tongji School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030;Experimental Study on Bidens Bipinnata L in Treating Renal Anemia[J];Research of Integrated Traditional Chinese and West Medicine;2009-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Qi,ZHANG Yan-na,CHEN Fei-hu(School of Pharmacy,Anhui Medical University,Hefei 230032,China);Research development in chemical constituents and pharmacological action of total flavonoids of Bidens bipinnata L.[J];Anhui Medical and Pharmaceutical Journal;2009-09
2 LIN Liqing,LIN Xinhua,HUANG Liying,ZHENG Yanjie,LI XiaoyanSchool of Pharmacy,Fujian Medical University,Fuzhou 350004,China;Anti-Tumor Activity of Extracts of Bidens bipinnata L in vitro[J];Journal of Fujian Medical University;2010-02
3 FU Da-hua1,LIU Zhi-li2a,LIU Jun-shi2b(1.Department of Preclinical Medicine,Zhangzhou Health Vacational College,Zhangzhou 363000,China; 2a.Department of Surgery; 2b.Department of Rehabilitation,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China);Effects of Bidens pilosa Linn Extract on Proliferation and Cell Cycle in Hela and A549 Cells[J];Acta Academiae Medicinae Jiangxi;2009-12
4 ZHANG Chuan-wei,WANG Yu-liang(Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China);Modern Research Progress of Bidens[J];Journal of Liaoning University of Traditional Chinese Medicine;2010-06
5 Tang Ying-Shuang1,Zhang Hong-bin1,Kanga Dragon2(1.323 Hospital of PLA,Xi'an 710054,China;2.PLA 451 Hospital,Xi'an 710054,China);Bidens chemical composition and pharmacological research[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2010-11
6 CHEN Fei-hu1,LU Yuan-qing1,SHEN Ji-jia2,REN Cui-ping2,YUAN Li-ping1,LI Jun1 1College of Pharmacy,2Department Microbiology & Parasitology,College of Basic Medical Sciences,Anhui Medical University,Hefei 230032,Anhui,China;Therapeutic effects of total flavones of bidens pilosa L on hepatic fibrosis in murine schistomiasis[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2007-09
7 HAN Shu-hai,ZHANG Xin-mu,CUI Chang-lei,et al.(The First Hospital of Jilin University,Changchun 130030,China);The protection of rhKD/APP against renal ischemia-reperfusion injury in rats[J];Chinese Journal of Laboratory Diagnosis;2008-09
8 Huang Xiaoou~1,Chen Zhuang~1,Deng Jiagang~2(1.Affiliated Ruikuang Hospital,Guangxi College of Traditional Chinese Medical, Nanning 530011,China 2.Guangxi College of Traditional Chinese Medical);Protective Effect of Mangiferin Dropping Pills on Experimental Liver Injury in Mice[J];China Pharmacist;2009-09
9 TAN Yongxia,LIU Chao,CHEN Ruoyun(Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine of Ministry of Education,Institute of Materia Medica,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100050,China);Phenolic constituents from stem bark of Morus wittiorum and their anti-inflammation and cytotoxicity[J];China Journal of Chinese Materia Medica;2010-20
10 LIN Li-qing,HUANG Li-ying,ZHENG Yan-jie,LIN Xin-hua(Faculty of Pharmacy,Fujian Medical University,Fujian Fuzhou 350004,China);Study on microwave extraction of total alkaloids from Bidens bipinnata L by orthogonal test[J];Chinese Journal of Hospital Pharmacy;2010-16
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 HE Jin-chao~1,YANG Li-li~1,MA Jie~1,YAN Bo-qun~2,HAN Shu-hai~1,HOU Li-zhong~1,YAN Wei-qun~(1)(1.Department of Biochemistry,Institute of Frontier Medical Sciences,Jilin University,Changchun 130021,China;2.Department of Digestive Medicine,Fourth Hospital,Jilin University,Changchun 130011,China);Large scale fermentation process and purification for rhKPI/AβPP in Pichia pastoris[J];Journal of Jilin University(Medicine Edition);2006-02
2 Cao Zhifang;Jia Lin;Jiang Rong;Gao Lihua;Pan Xuegong;Lu Deru (Institute of MedicalBiotechnology and Molecular Genetics,Second Military Medical University,Shanghai,200433);Effect of recombinant human erythropoietin on renal failure models induced by gentamycin in rats[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1995-06
3 LIU Weiping1),JIN Guoping2),CHEN Peibo1),WANG Yanping1),HE Wei1,3),PEI Guangjun1),ZHANG Hongquan1)1)College of Public Health,Zhengzhou University,Zhengzhou 450001 2)Department of Biochemistry,Zhengzhou University,Zhengzhou 450001 3)Institute of Medical Science of Henan Province,Zhengzhou 450052;Protective effect of aqueous extract of Dioscorea batatas against acute hepatic injury induced by CCl_4 in mice[J];Journal of Zhengzhou University(Medical Sciences);2008-05
4 Yu Zhao'an (Henan Nanyang Zhang Zhongjing Hospital, 473001);Study on Effect of Fresh Bidens bipinnanta L.on Reversal Hypertropy of the Left Ventricle in Hypertension and Cardiac Function[J];Primary Journal of Chinese Materia Medica;2001-03
5 Chen Xiaohu,Tang Shuhua,Li Yan,Jiang Weimin(Cardiac Department,Hospital Affiliated to Nanjing University of Traditional Chinese Medicine,Nanjing,210029);Beggarticks Granules in Hypertension and Hyperinsulinemia[J];JOURNAL OF NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1998-01
6 Da-Ming Feng, Shuang Wang, Ya-Lin Tang, Yong-Zong Yang, Gang-Zhi Zhu, Di-Zhong Yan, Department of Pathophysiology and Center of Molecular Biology Nanhua University, Hengyang 421001, Hunan Province, China;Protective effect of extraction from Hygrophila salicifolia on mice acute hepatic injury[J];World Chinese Journal of Digestology;2005-09
7 CHEN Fei-hu, YUAN Li-ping, ZHONG Ming-mei, XIA Li-juan, LI Jun College of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China;Protective effect of total flavones of Bidens pilosa L on experimental liver fibrosis in rats[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2006-12
8 WANG Hong-jiao, ZHANG Xin-mu, CHANG Shu-fang, et al.(The 461 Hospital of PLA, Changchun 130021, China);Protective Effect of aprotinin Agaist Acute Hepatic Injury in Mice[J];Chinese Journal of Laboratory Diagnosis;2005-03
9 BAI Zhen-zi1,SHENG Chuan-lun1,SU Xiu-fen2,et al.(1.Department of Infectious Disease,China-Japan Union Hospital,Jilin University,Changchun 130033,China;2.Department of Infectious Disease,First Hospital,Jilin University,Changchun 130021,China);Effects of Jiangzhitong on Carbon Tetrachloride-induced Fatty Liver[J];Chinese Journal of Laboratory Diagnosis;2008-12
10 Zhu Lixian, Jin Zhengyu (School of Food Science and Technology, Southern Yangtze University, Wuxi 214036);Effects of piceid on blood lipid metabolism, nitric oxide and nitricoxide synthase in experimental hyperlipidemia rats[J];Pharmacology and Clinics of Chinese Materia Medica;2005-03
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