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《Journal of Jilin University(Medicine Edition)》 2012-01
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Evaluation on curative effect of Self-prepared Softening Liver and Eliminating Fat Decoction in treatment of non-alcoholic steatohepatitis

YANG Qiang1,XIE Hui-chen1,PAN Qing-hua2,LIU Xiao-qin3,XU Jian-hua1, ZHAO Xiao-qin1,JIANG Jin-lin1(1.Department of Traditional Chinese Medicine,Affiliated Hospital,Hubei University for Nationalities, Enshi 445000,China;2.Department of Digestive Medicine,Central Hospital,Enshi Autonomous Prefecture, Enshi 445000,China;3.Department of Preventive Medicine,Center for Disease Control and Prevention of Enshi,Enshi Autonomous Prefecture,Enshi 445000,China)  
Objective To observe the clinical efficacy of Self-prepared Softening Liver and Eliminating Fat Decoction in treatment of non-alcoholic steatohepatitis(NASH).Methods 172 patients with NASH,according to the willingness of patients,were divided into western medicine treatment group(n=50),Chinese medicine treatment group(n=56),and combined treatment group with Chinese and western medicine(n=66).The patients in Western medicine treatment group were treated with oral western medicine for protecting the liver,reducing enzyme and lowering blood lipids,in traditional Chinese medicine group with Self-prepared Softening Liver and Eliminating Fat Decoction,in combined treatment group with western medicine combined with Chinese medicine,and lasted for 3 months.The liver function,serum lipids,liver image were observed.Results In combined treatment group,50 cases were cured,12 cases were effective,4 cases were ineffective,the cure rate was 75.8%,the total effective rate was 93.9%;in Chinese medicine treatment group,38 cases were cured,15 cases were effective,3 cases were ineffective,the cure rate was 67.9%,the total effective rate was 94.6%;in western medicine group,26 cases were cured,17 cases were effective,7 cases were ineffective,the cure rate was 52.0%,the total effective rate was 86.0%.In Chinese medicine treatment group and combined treatment group the cure rates and the total effective rates were significantly higher than those in western medicine group(P0.05 or P0.01);the cure rate in combined treatment group was higher than that in Chinese medicine treatment group(P0.05);the difference in effective rate between combined treatment group and Chinese treatment group had no significant difference(P 0.05).The serum ALT,AST,and GGT levels after treatment in three groups were lower than before treatment(P0.01);the ALT,AST,and GGT levels in Chinese medicine group and combined treatment group were lower than those in western medicine group(P0.05 or P0.01);the ALT,AST,and GGT levels after treatment in combined treatment group and Chinese medicine group had no significant difference(P 0.05).The serum TG and TC after treatment in three groups were decreased compared with before treatment,there were significant differences(P0.01);the TG and TC levels in Chinese medicine treatment group and combined treatment group were lower than those in western medicine group(P0.05 or P0.01);there were no significant difference in the TG and TC levels between Chinese medicine treatment group and combined treatment group(P0.05).In the course of treatment,some short-term gastrointestinal side effects occurred in western medicine group,but Chinese medicine treatment group and combined treatment group had no obvious adverse reactions.Conclusion Self-prepared Softening Liver and Eliminating Fat Decoction has the exact effect on NASH and has no adverse reactions;Self-prepared Softening Liver and Eliminating Fat Decoction combined with western medicine can significantly improve the clinical cure rate of NASH,and reduce the gastrointestinal tract reaction caused by western medicine.
【Fund】: 湖北省教育厅指导性项目资助课题(B20092905)
【CateGory Index】: R259
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