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《Journal of Jilin University(Medicine Edition)》 2012-02
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Protective effect of LHD on overtiredness rats and its mechanism

YANG Hong-xiu1,2,YU Xiao-feng1,QU Shao-chun1,XU Hua-li1,SUI Da-yun1(1.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China;2.Jilin Provincial Science and Technology Department,Changchun 130041,China)  
Objective To study the protective effect of Lubao Health cultivation Drink(LHD) on overtiredness rats induced by simulating swimming overtraining and investigate its mechanism.Methods The fatigue model was induced by simulating swimming overtraining for 8 weeks in rats.Male Wistar rats were divided randomly into 6 groups,including control group,general intensive swimming training group,overload swimming model group and low dose LHD group,middle dose LHD group and high dose LHD group.The rats in A,B and C groups were treated with(with 10mL·kg-1·d-1 i.g).The rats in D,E and F groups were treated with different concentrations of LHD distilled water(10 mL·kg-1·d-1 i.g).After 8 weeks,the changes of body weight,urine protein(UP),blood sugar(BG),hemoglobin(Hb),serum testosterone(ST) and plasma corticosterone(PC) contents in rats were determined.The contents of dopamine(DA),noradrenaline(NA),5-hydroxy tryptamine(5-HT) and γ-Aminobutyric acid(GABA) in hypothalamus were determined with sandwich ELISA method,and the ratios of DA/5-HT,NA/5-HT and DA/NA were calculated.Results Compared with overload swimming model group,in middle and high dose LHD groups the body weight loss induced by simulating swimming overtraining from 5 to 8 weeks wwas significantly improved and the UP contents were decrease(P0.05 or P0.01),but BG,Hb,ST and PC contents had no significant changes.In addition,in middle and high dose LHD groups the contents of 5-HT were decreased,and the content of DA and ratios of DA/5-HT,NA/5-HT and DA/NA in hypothalamus were increased(P0.05 or P0.01).Conclusion LHD has protective effects on overtiredness rats induced by swimming overtraining through decreasing the content of 5-HT,and increasing the contents of DA and GABA and ratios of DA/5-HT,NA/5-HT and DA/NA.
【Fund】: 吉林省长春市科技计划项目资助课题(长科技合2008206)
【CateGory Index】: R285.5
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