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《Journal of Jilin University(Medicine Edition)》 2016-04
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Protective effect of sevoflurane pretreatment on lung function of infants during cardiopulmonary bypass

CHEN Fang;MA Xinggang;MENG Baoying;ZHAO Lei;Department of Anesthesiology,Shenzhen Children's Hospital,Guangdong Province;Department of Cardiac and Chest Surgery,Shenzhen Children's Hospital,Guangdong Province;Department of Anesthesiology,Second Clinical Medical College,Jinan University,Shenzhen People's Hospital,Guangdong Province;  
Objective:To observe the influence of sevoflurane pretreatment in the lung function of the infants during heart operation by cardiopulmonary bypass(CPB),and to explore its lung protection and possible mechanism.Methods:Sixty infants with ventricular septal defect were enrolled at age less than 1year old and randomly assigned to pretreatment group and control group(n=30).After the induction of general anesthesia and tracheal intubation,the patients in pretreatment group received continuous inhalation of 1.0 MAC sevoflurane until the beginning of CPB.Inhale sevoflurane was absent in control group.The duration of ventilator support of the infants in two groups was recorded.The Pplate,CL,OI,A-aDO2,RI,the number of leukocytes and neutrophils segregated in lung of the patients were compared between two groups at the four time points T0(before aorta clamping),T1(30min after aorta declamping),T2,and T3(2hand 6hafter CPB).Results:Compared with control group,the duration of ventilator support of the infants in pretreatment group was obviously shortened(P0.05).In each group,the CL and OI were significantly decreased(P0.05 or P0.01),while the Pplate,A-aDO2,RI,the number of leukocyte and neutrophils segregated in lung were significantly increased(P0.05 or P0.01)at T1,T2,T3 time points compared with T0 time point.The CL and OI in pretreatment group were significantly increased(P0.05 or P0.01);the Pplate,A-aDO2,RI,the number of leukocytes and neutrophils segregated in lung in pretreatment group were significantly decreased at T1,T2,and T3(P0.05 or P0.01)compared with control group.Conclusion:Sevoflurane pretreatment might play a role in decreasing the leukocyte adhesion and protecting the lung function in the infants during opening heart operation by CPB.
【Fund】: 国家自然科学基金资助课题(81401570)
【CateGory Index】: R726.1
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