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Sodium channel blockadeeffectofthe secondary extract XIII-2of scorpion venom from Buthus martensii Karasch

Yang Shijie, Zhang Wenjie, Jiang Yan·, Wei Junjie, Zhang Hongiun (Department of Pharmacology,Centrai Laboratory of Physiology, Department of Organic Chemistry)  
Myocardiocytes of mice were cuitured. action potentials of fast respond myocar-diocytes were recorded with microelectrodes inside the cells. the secondary extract of scorpionvenom from buthus martensii Karasch XIII-2 3μg·mL-1 decreased all of the depolarizationconcerned parameters without influence on the duration and discharging rate of action potentials.These effects disappeared immediately after washing-out. in a similar way, the depolarizationconcerned parameters were decreased by deactivating the sodium channels experimentally. Thesedepolarization concerned parameters remained unchanged after exposure to calcium channel block-er. The results indicated that XIII-2 has simple sodium channel blockade action.
【CateGory Index】: R996.3
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