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EffectGASDon learning and memory in the dementia rats induced by hippocampal lesions due to quinolinc acid

Song Qianliu,Zong Ru( Dept.of Pharmacology,The school of Basic Medical Sciences )  
By one trial passive avoidance response step-down tast and water maze spatial local-ization tast, we observed the effect of GASD on pathological models of the dementia rats induced byhippocampal lesions due to quinolinic acid. The results suggested that GASD could improve learningand memory deficiency in rats with bilateral hippocampal lesions after administration of quinolinicacid.The major mechanism of GASD might relate to the regulation of the glutamatergic functionthereby preventing the neurotoxicity of quinolinic acid.
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