Effect of Milingwang on immunofunctions of Swiss mice and naked mice
Chang Yaping,Wu Yin*,Wang Shuhe,et al(Dept.of Immunology,NB Univ of Medical Sciences;Northeast Normal University)
The immunofunctions of Swiss mice and nude mice administered with effective dose of Milingwang (MLW) agent in stomach were observed.The results showed that MLW could evidently promote the reactivity of T lymphocytes and B lymphocytes of Swiss mice to mitogens,sponteneous proliferation of thymus and bone marrow cells,and ability of producting interleukin-1 and interleukin-6 of splenocytes (P001).MLW could only increase the reactivity of B lymphocytes of nude mice to glycyrrhiza uralensis fisch polysaccharide (GPS) (P005).Compared to thoes of Swiss mice,nude mice′s parameters of reativity of B lymphocytes to lipopolysaccharide (LPS) and GPS,sponteneous proliferation of bone marrow cells and sera circle immune complex (CIC) level were higher (P005).However, the parameters of sponteneous proliferation of thymocytes,sera lysozyme level,level of arginase in macrophages of spleen were lower (P005).It may be suggested that MLW has different immune regulation effect on normal Swiss mice and immunodeficiency mice.
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