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Effect of Milingwang on immunofunctions of Swiss mice and naked mice

Chang Yaping,Wu Yin*,Wang Shuhe,et al(Dept.of Immunology,NB Univ of Medical Sciences;Northeast Normal University)  
The immunofunctions of Swiss mice and nude mice administered with effective dose of Milingwang (MLW) agent in stomach were observed.The results showed that MLW could evidently promote the reactivity of T lymphocytes and B lymphocytes of Swiss mice to mitogens,sponteneous proliferation of thymus and bone marrow cells,and ability of producting interleukin-1 and interleukin-6 of splenocytes (P001).MLW could only increase the reactivity of B lymphocytes of nude mice to glycyrrhiza uralensis fisch polysaccharide (GPS) (P005).Compared to thoes of Swiss mice,nude mice′s parameters of reativity of B lymphocytes to lipopolysaccharide (LPS) and GPS,sponteneous proliferation of bone marrow cells and sera circle immune complex (CIC) level were higher (P005).However, the parameters of sponteneous proliferation of thymocytes,sera lysozyme level,level of arginase in macrophages of spleen were lower (P005).It may be suggested that MLW has different immune regulation effect on normal Swiss mice and immunodeficiency mice.
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