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《JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE》 1998-03
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Effects of ginsenosides on myocardial ischemia and reperfusioninjury and concentrationeffect relationship

Zhang Jiemin,Chen Libo,Zhao Hongxu,Wang Yong,Tong Li(Dept.of Cardiovascular Surgery,The Third Clinical College,Changchun)  
Objective:To study the effects of ginsenosides (GS) on myocardial ischemia and reperfusion injury,and concentrationeffect relationship.Methods:①Eleven mongral dogs were divided into 2 groups randomly and cardiopulmonary bypass was estabilished.In GS group,20 mg/L of GS was added into the cardioplegia.The indexes of myocardial dynamics and hemodynamics were recorded at 15 min after aortic unclamping.The samples were taken from the right ventricle and mitochodria were scored under electron microscope at 60 min of aortic crossclamp and 15 min after unclamping of aorta.②Thirty rabbits were divided into 5 groups randomly,and then isolated working hearts underwent 60 min normothermic ischemia by aortic crossclamping.In GS group 20,40,80,160 mg/L of GS were added into the cardioplegia respectively..As mentioned above,the parameters (at 25 min of aortic unclamping) and the myocardial samples were obtained.In addition the contents of calcium in the cardium were measured.Results:Before and after the dogs′cardiopulmonary bypass and the isolated rabbit hearts′working were established,the data of myocardial dynamics (±dp/dtmax),hemodynamics (CI),mitochodria score and the myocardial calcium content in GS group were better than those in control group (P0001),and those in GS 80 mg/L group better than those in 20 and 40 mg/L groups,whereas all the data mentioned above in GS 160 mg/L group were lower than those in control gorup.Conclusion:①GS 20 ̄80 mg/L has significantly protective effect on the myocardial ischemia and reperfusion injury,and the effects increase when the concentration of GS increases;whereas the effects are converse when the concentration of GS was 160 mg/L.②GS has the calcium channel block effect.
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 10 Hits
1 CHEN De-jun;LIN Yue-tao;CHEN Yi-bin;Puning Overseas Chinese Hospital;;A clinical study of shenfu injection on treatment for hypotension in patients with acute myocardial infarction after percutaneous coronary intervention[J];岭南心血管病杂志;2015-06
2 LU Xin-sheng et al (Gansu Normal University Nationalities Chemistry and the Life sciences Department,Hezuo,Gansu 747000);Sapodilla plum Pharmacology Activeness Research Development[J];安徽农业科学;2010-24
3 MIN Su LIN Jing-yan ZHANG Zu-lie Department of Anesthesiology,First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China;Protective effect of Shenfu injectio pretreatment on myocardium against ischemia-reperfusion injury in diabetic rabbits[J];中华麻醉学杂志;2006-06
4 WANG Qiang~1 , MO Xue-mei~2, YANG Xiao-ying~1, HE Jing-song~1 (1.Department of Cardiology,Ruikang Hospital Affiliated to Guangxi Traditional Chinese Medical College, Nanning 530011, China; 2.Guangxi General Hospital of Police, Nanning 530012, China);Treatment of Cardiovascular Diseases with Ginsenosides[J];心血管病学进展;2006-03
5 CAO Jun MIN Su.Department of Anesthesiology,First Affiliated to Hospital,Chongqing University of Medical Science,Chongqing 400016,China;Protective effects of cardioplegic solution containing Shenfu injectio on isolated rabbit heart against ischemia-reperfusion injury[J];中华麻醉学杂志;2006-01
6 Zhao Huayun,et al;The Effects of Shenqi Decoction(参芪汤) on the Gene Expression of Endothelins in Rats with Myocardium Ischemia[J];中国中医急症;2005-08
7 Li Li yan, Lu Xin guo, Department of Hum an Sports Science,Yangzhou University, Yangzhou 225001,Jiangsu Province,China;Effect of ginsenoside on cardiovascular and neurological systems and its role against exercise-induced fatigue[J];中国临床康复;2005-16
8 WANG Chao,HU Gao,LIU Yan,ZHOU Qing,SHAO Gang,LI Yuan-lan (Grade 2001,Faculty of Medicine,Bengbu Medical College,Bengbu 233003,China);Influence of ginsenosides on contractility of fatigued diaphragm in rats[J];蚌埠医学院学报;2005-02
9 Jian Qin,Shu-Qing Chen,Jun Meng,Ming-Hua Jin,Wei-Jun ZhangJian Qin,Shu-Qing Chen,Jun Meng,Ming-Hua Jin,Wei-Jun Zhang,Department of Traditional Chinese Medicine,First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,Guangdong Province,China;Effects of shenqi decoction on the gene expression of endothelins in rats with myocardial ischemia[J];中国临床康复;2004-33
10 ZHENG Shu yun, XU Jian guo, ZHAO Zhen zhong Clinical School of Medicine, Nanjing University, Nanjing (210002);The Protective Effect of Shenfu Injection on Myocardium against Ischemia Reperfusion Injury in Rats[J];中国中西医结合杂志;2004-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Hu Huailing;Li Qun;Jiang Chunfa;Qiu Quanhuang;Department of Emergency,Houjie Hospital of Dongguan;;Risk factors of hypotension after emergency percutaneous coronary intervention in acute myocardial infraction patients[J];临床荟萃;2015-01
2 HOU Ya-zhu1,MAO Jing-yuan2*,WANG Xian-liang2,LI Jia1,LIU Chun-xiang1 1.Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China 2.Cardiovascular Department,The First Teaching Hospital,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Shenfu Injection for Patients with Heart Failure: A Systematic Review[J];中国循证医学杂志;2011-03
3 SU Jian-qing~1,CHU Xiu-ling~1,WEI Xu-bin~2 1.Agricultural School of Liaocheng University,Liaocheng,Shandong 252000;2.College of Animal Science and Veterinary Medicine;Jilin University;Changchun 130062;3.College of Animal Science,Guizhou University,Guiyang 550025;Effects of Proliferation of CEF with Ginsenoside and Its Derivatives[J];Agricultural Science & Technology;2009-06
4 DENG Jing,JIANG Yong-xin The 3 rd Affiliated Hospital of Kunming Medical College,Yunnan Tumor Hospital and Institute,Kunming 650001,China;Advance on antitumor activity of ginsenoside CK[J];现代肿瘤医学;2009-11
5 HU Jin-ling,LI Feng-jun,HU Chun-rong,ZHANG Chun-ye Department of Emergency,the First Hospital of Jiamusi University,Jiamusi,Heilongjiang,154002,China;Protective effect of Shenfu injection on myocardium during cardiopulmonary resuscitation[J];心血管康复医学杂志;2009-01
6 TANG Zi - ren, LI Chun - sheng Department of Emergency, Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China;Effect of Shenfu injection on hemodynamics of hypovolemic shock and oxygen delivery[J];中国病理生理杂志;2005-10
7 WANG Ji-yan~(1,2), SUN Guang-zhi~1, LI Xiang-gao~1 (1. College of Chinese Medicinal Material, Jilin Agricultural University, Changchun 130118, China; 2. Changchun College of Triditional Chinese Medicine,Changchun 130021, China);A Review of the Studies on Chemical Constituents and Pharmaceutical Activities of the Fruit of Panax ginseng[J];吉林农业大学学报;2005-01
8 LI Xiang-gao ( College of Chinese Medicinal Materials , Jilin Agricultural University, Changchun 130118, China);Studies on Pharmacological Activity of Gisenoside-Rb_1[J];吉林农业大学学报;2004-06
9 Ni Ming, Cai Guangxian, Lei Xinqiang, et al (Hunan Academy of Traditional Chinese Medicine, Changsha 410006);The Effects of Xinkang Granule on Hemodynamics and Oxygen Consumption of Myocardium among Dogs[J];湖南中医学院学报;2004-06
10 ZHENG Zhenzhong 1 LIU Zhengxiang 1 LIU Xiaochun 2( 1Department of Cardiology, Tongji Hospital,Tongji Medical College, Huazhong University of Science and Technology , Wuhan,430030, China; 2Department of Neurobiology , Tongji Medical College,Huazhong University of Science and Technology);Effect of ginsenoside Re on the infiltration of polymorphonuclear neutrophils and the activity of MPO after ischemia and reperfusion in rats[J];临床心血管病杂志;2004-12
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 Ruan Wenshuo;Yangjiang People' s Hospital;;Comparative Effect of Rosuvastatin and Atorvastatin in Treating Premature Coronary Heart Disease and Acute Myocardial Infarction[J];中国药业;2017-18
2 MIAO Yunfei;YU Weiping;LI Jun;ZHANG Yu;ZHENG Wenxian;Department of Anesthesiology,Zhejiang Provincial Hospital of TCM;Wenzhou Medical University;Department of Anesthesiology,the Second Affiliated Hospital of Wenzhou Medical University;Department of Orthopedics,the Second Affiliated Hospital of Wenzhou Medical University;;Effect of Shenfu injection on E,P-selection during perioperative period of elderly patients receiving total hip replacement[J];中国现代医生;2017-18
3 JIN Yan-yan;GAO Hai;ZHANG Xin-yong;AI Hui;ZHU Xiao-lin;WANG Jing;Emergency and Critical Care Center,Beijing Anzhen Hospital,Capital Medical University;;Shenfu Injection(参附注射液) Inhibits Inflammation in Patients with Acute Myocardial Infarction Complicated by Cardiac Shock[J];Chinese Journal of Integrative Medicine;2017-03
4 Wu Hui-zhen;Jia Qing-zhong;Department of Pharmacy,Hebei Provincial People's Hospital;Department of Pharmacology,Hebei Medical University;;Protective effects of ginsenoside Rb_3 on a rat model of ischemia/reperfusion injury[J];中国组织工程研究;2016-49
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