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Effect of cadmium on genetic toxicity and protection of CortexAcanthopanasia Radicis against genetic damage induced by codmium

Liu Bing1,Pang Huimin1,Chen Minyi2 (1\ Department of Medical Genetics,NBUMS;2\ Xinhua Hospital,Shanghai Second Medical University)  
Objective and Methods:The test of sperm aberration and micronucleus of bone marrow cells in mice were used to detect the mutagenicity of cadmium and antimutagenicity of Cortex Acanthopanasia Radicis (CAR) on germ cell and somatic cell.Kunming mice were divided randomly into four groups:normal saline control group (NS):MMC control group (MMC 1.0 mg/kg);Cdmutate group (1/5 LD50),176 mg/kg);CAR antimutate group (CAR 1,2,4 g/kg+Cd).Ridit test and 2 were used to evaluate the statistical significance of the date.Results:The experiment demonstrated that Chinese medicine CAR can significantly decrease sperm aberration and micronuclei frequencies induced by Cd (P001).Conclusion:As an antimutagen CAR has practical value in occupational protection against genetic damage induced by Cd.
【Fund】: 国家自然科学基金
【CateGory Index】: R995
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