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《Journal of Bethune Military Medical College》 2008-04
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Clinical Research on Recurrent Breast Cancer Treatment with Gemcitabine Combined with Carboplatin

YU Gengsheng,LV Huazhu.LI Chunming.Department of Oncology,Jiangmen Central Hospital,Jiangmen 529070,China  
Objective To investigate the effect and toxicity of gemcitabine combined with carboplatin treatment on recurrent breast cancer.Methods On the first day and eighth day,gemcitabine(1200 mg/m2) was diluted with physiologic saline and then used through intravenous drip.on the second day,350 mg/m2 carboplatin dissolved in 5% glucose solution(500 ml) was used.One cycle lasted for 21 days.Results Among 40 patients,there were 1 complete response(2.5%),16 partial responses(40.0%),15 stable(37.5.0%),8 progressive(20.0%).The total effective rate was 42.5%.Median time to progression was 4.8 months and 1-year survival rate was 47.5%.The common toxicities included nausea,vomiting,bone marrow depression and rash.Conclusion The gemcitabine combined with carboplatin for the treatmend of recurrent breast cancer is effective and has endurable toxicities and deserves promoting.
【CateGory Index】: R737.9
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2 MIAO Jian-hua,ZHANG Jia-wei,YAN Zi-he.Department of Oncology,Wuxi Second People's Hospital,Wuxi 214002,China;The chemotherapy regimen based on cisplatin in the treatment of metastatic breast cancer[J];Chinese Clinical Oncology;2008-02
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