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《Journal of Bethune Military Medical College》 2010-02
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Effects of valsartan on the expression of α-SMA amd MCP-1 in rats with unilateral ureteral obstruction

LI Zengming,DING Yueling.Department of Sports and Body Sciences,Hebei Institute of Physical Education,Shijiazhuang,Hebei 050041,China  
Objective To observe the characteristics,meaning and effects of the expression of α-smooth muscle actin(α-SMA)and monocyte chemoattractant protein-1(MCP-1) after unilateral ureteral obstruction(UUO) in rats and intervention of valsartan.Methods The model group were made by UUO.Immunohistochemical method and pathologic image were used to make positive expression position and albumen expression semiquantitative analysis so as to observe the expression of α-SMA and MCP-1 in rats.Results The expression of α-SMA and MCP-1was positive in the model group.Protein semi-quantitative analysis of α-SMA and MCP-1 was obviously higher than those of the control group(P 0.01)while obviously lower than those of the valsartan group(P 0.01).Conclusions The model group has cell phenotype conversion among the kidney tubules.Valsartan can inhibit the production of MCP-1,restrain inflammation enlargement,relieve the expression of α-SMA,restrain the expression of MCP-1 and inhabit the phenotype conversion of interstitial cells in the kidney tubules.
【CateGory Index】: R692
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