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《Journal of Beijing Normal University(Natural Science)》 2000-06
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RELATIONSHIP BETWEEN PHOSPHOLIPASE A_2 ACTIVATION MEDIATED BY G PROTEIN βγ SUBUNIT AND β-ADRENERGIC RECEPTOR DESENSITIZATION

Xiao Xueyuan 1) Ge Xueming 2) An Mingbang 2) Lü Baozhang 2) ( 1)Education Ministry Key Laboratory of Cell Proliferation and Regulation Biology, Beijing Normal University, 100875, Beijing, China; 2)Institute of Basic Medical Scie  
To elicit the mechanism of β AR coupling to PLA 2 , the relationship between isoproterenol (ISO) induced β AR binding capacity and phospholipase A 2 (PLA 2 ) activation in rat lung tissue is investigated in vitro. β AR down regulation and PLA 2 activation induced by ISO in rat lung tissues display dose and time dependent manner. However, the activation of PLA 2 is more sensitive than β AR down regulation as shown by dose effect. The changes mentioned above are effectively abolished when p bromoacetophenone (PBA), pertussis toxin (PTX), dexamethasone (DEX) ,anti Giα and anti Gβγ serum are involved respectively in the reaction system . On the other hand, the addition of GTP γ S ,which binds to Gα subunit with high affinity and releases free Gβγ, aggravates β AR down regulation and PLA 2 activity during coincubation with ISO. These data suggest that long term treatment of rat lung tissues with ISO can lead to β AR down regulation , while the signal transduction pathway is also switched from adenylate cyclase(AC) positive coupled to PLA 2 activation which is mediated by Gβγ.
【Fund】: 国家自然科学基金重点资助项目!(392 30 35 0 )
【CateGory Index】: R341
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