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《Journal of Beijing Normal University(Natural Science)》 2001-05
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STUDY ON THE ELECTROCHEMICAL BEHAVIOR OF MTX AND ITS APPLICATION

Hu Jingbo 1) Yang Shuiyan 1) Sun Zijie 2) Li Qilong 1) ( 1)Departmwnt of Chemistry, Beijing Normal University, 100875,Beijing, China; 2)Departmwnt of Chemistry, Beijing University of Science and Technology, 100083,Beijing, China)  
In a buffer solution of 0.10 mol·L -1 NH 3 -NH 4 Cl(pH 9.8), a sensitive reduction derivative peak of methotrexate is obtained by single-sweep oscillopolarography. The peak potential is -0.83 V(vs.SCE). The peak current is proportional to the concentration of methotrexate over the range of 5.4×10 -8 ~6.5×10 -6 mol·L -1 with the detection limit of 4.33× 10 -8 mol·L -1 . This method is applied to determination of methotrexate in tablets with a satisfactory result. The electrochemical behavior and reaction mechanism of the system are studied at a hanging mercury drop electrode by linear and cyclic voltammetry. The experiments indicate that the electrode reduction process is guasi-reversible with adsorptive characteristics.
【Fund】: 国家自然科学基金资助项目 ( 2 9875 0 0 3 )
【CateGory Index】: O657.1
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