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《Journal of Beijing Normal University(Natural Science)》 2006-01
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SEPARATION OF QUINOLONES BY CAPILLARY ELECTROPHORESIS

Wu Lingli Qin Weidong(College of Chemistry,Beijing Normal University,100875,Beijing,China)  
The aim of this work is to separate quinolones,namely,Lomefloxacin,Ciprofloxacin,Fleroxacin,Ofloxacin and Pazufloxacin,by means of high performance capillary electrophoresis.The parameters such as separation voltage,buffer concentration and pH,and injection time are studied.The separation conditions are: 40()mmol·L~(-1) sodium borate-potassium dihydrogen phosphate buffer at pH 8.86,50()μm×40cm(24cm effective length)capillary and 5()s injection;the separation voltage is +5()kV and the detection wavelength is set at 254()nm.The detection limits of the 5 quinolones are in the range of 1.5~7()mg·L~(-1).Under the above experimental conditions,the effective content of the commercial Fleroxacin pill is detected to be 48.0%.
【Fund】: 北京师范大学科研启动基金资助项目(102107103)
【CateGory Index】: R927
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