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《Journal of Baotou Medical College》 2010-01
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An Experimental Study on Conjunctival ECM Transplantation

XIN Xiangyang,GAO Lili.(Department of Ophthalmology,The Third Affiliated Hospital of Inner Mongolia Medical College,Baotou 014010,China)  
Objective: To investigate the characteristics and the effect of conjunctival extracellular matrix(ECM) and Amniotic membrane as a succedaneum for conjunctiva.Methods: 30 New Zealand rabbits were raised for the experiment.The conjunctival defect models were made of bulber conjunctiva from six rabbits and then all others were randomly divided into the test group(12 Rabbits) and the control group(12 rabbits).The conjunctival defect in the test group was repaired with conjunctival ECM and that in the control group was repaired with transplantation of the refrigerated amniotic membrane.All of them were photographed and examined by light microscope,immunohistochemical examination and lymphocyte toxicity test.Results: There were blood vessels growing into the grafts one week after conjunctival ECM transplantation in the test group and the grafts became mildly congestive and similar to normal conjunctival ones in the 8th week,without any immunologic rejection.Epithelium in the grafts could be seen through the light microscope to grow close to the normal one 4 weeks after transplation.But in the control group,the grafts were not completely covered with epithelium 4 weeks after transplantation.Onclusion: Conjunctival ECM has the characteristics of tissue activity and low antigenicity.It is an ideal conjunctival succedaneum for conjunctiva in conjunctiva transplantation and could be used as a graft to reconstruct ocular surface as well.
【CateGory Index】: R779.6
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