Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Leukemia》 1998-03
Add to Favorite Get Latest Update

IN VITRO STUDY ON EFECT OF TWO DIFFERENT ARSENICALS ON NB4 CELLS PROLIFERATION AND PROGRAMMED CELL DEATH

Li Jing;Sun Guanlin;Su Hut;et al(Affiliated Hospital Of Zhen Jiang Medical COllege Jiangsu, 212002)  
Cell morphology, cell growth curve, CFU-L.CFU-GM.BFU-E culture in intro, DNA electrophoresis, flow cytometry, p53 and Bcl-2 protein expression were used to study the mechanisms of the arsenicals treatment for leukemia. The results indicate that arsenic trioxide (As,O, )and arsenic disulfide (As2S2) can show a significant cytolytic effect on NB4. Arsenicals might also appear inhibitive activity for CFU-L of NB4.CFU-GM of BFU-E of bone marrow in normal human. Inhibitive activity of As2O3 is higher than that of As2S2.Programmed cell death in NB4 can be induced by both of the arsenicals. The mechanisms of the induction of programmed cell death may be associated with overexpression of p53 and Bcl-2 protein.
【Key Words】: NB4 cell Programmed cell death Arseiv trioxide Arsenic disulfide
【CateGory Index】: R730.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 WANG Zhan xiang,LIAO Jun xian, XU Yong gang, et al. Xiyuan Hospital, China Academy of Traditional Chinese Medicine,(Beijing,100091) $$$$[;INFLUENCE OF ANTIOXIDANTS ON APOPTOSIS INDUCED BY ARSENIC TRIOXIDE[J];JOURNAL OF LEUKEMIA;2000-03
2 NIU Qiao-hong LI Bing-ying Department of Hematology,Shanxi Cancer Hospital,Taiyuan 030013,China;Investigation of treatment of leukemia with realgar in China:literature review[J];Journal of Leukemia & Lymphoma;2007-04
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Li Jing, Sun Guanlin, Li Xiusong, et al Affiliated Hospital of Zhen Jiang Medical College, Jiangsu 212001;STUDY ON CFU GM、CFU L CULTURE IN VITRO AND CYTOGENETIC 42 MYELODYSPLASTIC SYNDROME[J];JOURNAL OF LEUKEMIA;1997-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Chen, HUANG Shi lin, XIANG Yang(The Institute of Traditional Chinese Medicine Hematology,the??210th Hospital, PLA, Liaoning Dalian 116021, China);Effect of Realgar on Apoptosis in Raji Cells[J];Journal of Anhui Traditional Chinese Medical College;2003-02
2 HE Zhi jie1*, ZHU Xing min2, CAI Wei bo1, CHEN Zhao hua3, XU Hong xing3, WU Yuan jian31.Department of Hematology, Suzhou Second Peoples Hospital, Suzhou 215002, P.R.China2. Department of Hematology, Affiliated Children Hospital of Suzhou Universit;Experimental Study on Apoptosis and Necrosis of HumanLeukemia Cell Line HL-60 Induced by As_2S_3[J];Chinese Journal of Cancer;2001-08
3 Cai Yun,Wang Mingchun,Chen Junxiong,et al Shenzhen Red Cross Hospital(Shenzhen,518029)$$$$;TREATMENT FOR 7 CASES OF ACUTE PROMYELOCYTIC LEUKEMIA BY SEQUENTIALLY USING ARSENIC TRIOXIDE AND COMBINATION CHEMOTHERAPY[J];Journal of Leukemia;1999-06
4 NIU Qiao-hong LI Bing-ying Department of Hematology,Shanxi Cancer Hospital,Taiyuan 030013,China;Investigation of treatment of leukemia with realgar in China:literature review[J];Journal of Leukemia & Lymphoma;2007-04
5 WANG Shu-ting, LI Qing,LIU Chao, YU Li-min,LU Bu-feng, YANG Pei-man(Medical College, Dalian University, Dalian 116622, China; Rey Laboratory of Celular and MolecularBiology of Liaoning Province, Dalian Medical University, Dalian 116027, China);Studies on As2O3 on Reversal of Multidrug Resistance in K562/ADM Cell Line[J];Journal of Dalian University;2002-02
6 Cai Hongpei, Deng Zhihua, Li Shi, Zhang Xingrong, Sheng Jianwei, Liu Su (Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003);As 2O 3 induces apoptosis of human gastric cancer cells[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1999-09
7 Zhang Chen,Huang Shilin,Yu Limin,et alInstitute of Chinese Traditioncal Medicine for Hematology,The 210th Hospital of PLA;Arsenic bisulfide induces apoptosis in K562 cells[J];JOURNAL OF DALIAN MEDICAL UNIVERSITY;1998-03
8 Zhang Chen,Huang Shilin,Zou Lijuan,et al Institute of Chinese Medical Hematology,The 210th Hospital;Realgar induces apoptosis of K562/ADM cells[J];JOURNAL OF DALIAN MEDICAL UNIVERSITY;1999-01
9 XIANG Yang, CHEN Nan-Nan, ZHANG De-Jie,HUANG Shi-Lin,LI Yue-Meng Department of TCM & Hematology, 210th Hospital of Chinese PLA, Dalian 116021, China;Establishment of serum pharmacology testing method for Compound Realgar Natural Indigo Tablets[J];Journal of The Fourth Military Medical University;2005-17
10 LIU Jing Sheng,LU Zhan Jun,DONG Lan Feng,et al.Hebei Academy of Medical Sciences,Shijiazhuang 050021;Experimental study of inducing effect of Realgar on tumor cells[J];Hebei Journal of Traditional Chinese Medicine;2000-11
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Chen, HUANG Shi lin, XIANG Yang(The Institute of Traditional Chinese Medicine Hematology,the??210th Hospital, PLA, Liaoning Dalian 116021, China);Effect of Realgar on Apoptosis in Raji Cells[J];Journal of Anhui Traditional Chinese Medical College;2003-02
2 HE Zhi jie1*, ZHU Xing min2, CAI Wei bo1, CHEN Zhao hua3, XU Hong xing3, WU Yuan jian31.Department of Hematology, Suzhou Second Peoples Hospital, Suzhou 215002, P.R.China2. Department of Hematology, Affiliated Children Hospital of Suzhou Universit;Experimental Study on Apoptosis and Necrosis of HumanLeukemia Cell Line HL-60 Induced by As_2S_3[J];Chinese Journal of Cancer;2001-08
3 Miao Tusheng Traditional Chinese Medicine H ospital of L in'an City,Zhejiag Province,(31130 0 );Clinical Observation of 5 0 Gases of Acute L eukemia Transferred from Chronic Granulocytic One Treated by Kangbailin with Zero- point Chemotherapy[J];Journal of Zhejiang College of Tcm;2000-05
4 Li Jing, Sun Guanlin, Li Xiusong, et al Affiliated Hospital of Zhen Jiang Medical College, Jiangsu 212001;STUDY ON CFU GM、CFU L CULTURE IN VITRO AND CYTOGENETIC 42 MYELODYSPLASTIC SYNDROME[J];JOURNAL OF LEUKEMIA;1997-01
5 Zheng Xiaofei,Li Xinquan,Wang Shengqi, et al .WT5BXInstitute of Radiation Medicine,Academy of Military Medical Sciences(Beijing,100850);ANALYSIS OF TELOMERASE ACTIVITY IN LEUKEMICCELLS AND NORMAL LEUCOCYTES[J];JOURNAL OF LEUKEMIA;1999-03
6 LU Dao pei, JIANG Bin, QIU Jing Ying (Institute of Hematology, Peking University, Beijing 100044, China);Acute promyelocytic leukemia treated by diarsenic trisulfide——The first case report[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;2000-03
7 LU Dao-Pei △, WANG Qin, LIU Yan-Fang, WANG Feng-Rong, JIANG Bin, LIU Kai-Y an, LIU Yan-Rong, CHEN Shan-Shan (Institute of Hematology, Peking University People's Hospital, Beijing 1000 44, China);Advance in the treatment of ac ute promyelocytic leukemia in China[J];Journal of Beijing Medical University;2002-05
8 CHEN Si Yu, LIU Shan Xi, LI Xin Min First Hospital, Xi'an Jiaotong Uiversity, Xi'an 710061, China;Expression of Bcl-2 and Bax in arsenic sulfide induced-apoptosis of K562 cell[J];Journal of The Fourth Military Medical University;2002-09
9 Lu Guangming, et al Research Laboratory of Trace Element,General Hospital of P. L. A. ,Beijing;STUDY ON LEVELS AND SPECIES OF ARSENIC EXPOSURE THROUGH THE DRINKING WATER TO THE POPULATION OF CHRONIC ENDEMIC ARSENISM AREA IN INNER MONGOLIA[J];Chinese Journal of Control of Endemic Disease;1997-05
10 Hao Baohong (Department of Mechanical Engineering. Beijing Institute of Petro-chemical Technology)Zheng Shuilin; Mao Jufan(Beijing Graduate Branch. Wuhan University of Technology);Discussion on Phenomenon of Granulation in Superfine-grinding Process[J];;1997-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Yang Zhiqiang~1 Li Fengyan~1 Li Qingjie~1 Zhao Tianbo~2(1 Department of Chemical Engineering, Beijing Institute of Petro-chemical Technology, Beijing 102617;2 School of Science, Beijing Institute of Technology, Beijing 100081);Using Method of Spot of As to Measure As Content[J];Journal of Beijing Institufe of Petrochemical Technology;2005-02
2 NIU Qiao-hong LI Bing-ying Department of Hematology,Shanxi Cancer Hospital,Taiyuan 030013,China;Investigation of treatment of leukemia with realgar in China:literature review[J];Journal of Leukemia & Lymphoma;2007-04
3 GU Jie1,SHI Wei-hua2,WEN Xiao-hua2,ZHANG Zuo2,HE Zhong-fa2,SHAO Chao-ying1(1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;2. Shanghai Institute of Geological Survey, Shanghai 200072, China);The Method of Arsenic Speciation[J];Journal of Donghua University(Natural Science);2009-01
4 GUO Li-xia,WANG Yuan-liang,XIN Juan nistry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China);Reserarch advance on mechanism of arsenic trioxide on tumor[J];Journal of Chongqing University(Natural Science Edition);2004-08
5 WANG Yu-ling~(1),QI Jun-sheng~(1),WANG Yuan-liang~(2),ZHANG Wen~(3) (1.Department of Chemical Engineering,Chongqing Three Gorges University, Wanzhou 404000,China;2.College of Bioengineering,Chongqing University,Chongqing 400030,China;3.Department of Society Development,Chongqing Municipal Science and Technology Commission,Chongqing 400175,China);Effect of SOD on Apoptotsis of Arsenic Compound Induced[J];Journal of Chongqing University(Natural Science Edition);2005-09
6 WANG Yan-yan,LIU Peng,HONG Yan,LIU Shuang,PIAO Feng-yuan (Dalian Medical University,Dalian 116044 China);Expression of 8-Hydroxy-2'-desoxyguanosine in the Cardiac Muscle Cell of Mice Exposed Chronically to Arsenic[J];Industrial Health and Occupational Diseases;2008-04
7 YU Yun-jiang,WANG Fei-fei,FANG Ji-dun,et al.Chinese Reseach Academy of Environmental Scicences,Beijing 100012,China;Advance in Research on Environmental Arsenic Pollution to Human Health[J];Journal of Environment and Health;2007-03
8 LI Yuan-hui,KANG Chao-sheng,LI Na,et al. Department of Histology and Embryology,Guiyang Medical College,Guiyang,Guizhou 550004,China;Expression of Caspase-3 in Renal Glomerulus Cells in Rats with Sub-chronic Arsenic Poisoning[J];Journal of Environment and Health;2008-05
9 Ye Xiaochuan~1 Yang Xiangliang~1 Xu Huibi~ 2 (1.College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; 2.College of Chemistry and Chemical Technology, Huazhong University of Science and Technology, Wuhan 430074, China);Advance in Nanorealgar Studies[J];Progress in Chemistry;2009-05
10 LU Jin,ZHA Qing-gui,MIAO Zhong,et al(Department of Haematology,Traditional Chinese Medical Hospital of Xinghua City,Jiangsu Province,Xinghua 225700,China);Clinical observation of acute promyelocytic leukemia after complete remission by sequential treatment of compound huangdai tablets,all-trans retinoic acid and chemotherapy[J];Jilin Medical Journal;2007-17
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved