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《JOURNAL OF LEUKEMIA》 2000-03
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INFLUENCE OF ANTIOXIDANTS ON APOPTOSIS INDUCED BY ARSENIC TRIOXIDE

WANG Zhan xiang,LIAO Jun xian, XU Yong gang, et al. Xiyuan Hospital, China Academy of Traditional Chinese Medicine,(Beijing,100091) $$$$[  
Objective:To explore the relationship between intercellular antioxidant and apoptosis induced by arsenic trioxide. Methods:The in vitro effect of different antioxidants on apoptosis of HL 60 cell induced by arsenic trioxide was studied with flow cytometery. Results:superoxide dismutase (SOD), catalase (CAT), vitamine C, CYS blocked apoptosis induced by As 2O 3.As 2O 3 mainly induced apoptosis of HL 60 cell in G 2 M phrase. As 2O 3 slightly inhibited tetolemerase activity. Conclusion:As 2O 3 binding with intercellular SII and enzymes, decreased the antioxidant function of the cells. This might be one of the mechanisms of apoptosis induced by arsenic trioxide.
【CateGory Index】: R73-36
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