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《Journal of Leukemia & Lymphoma》 2003-04
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THE EFFECT ON REBESCENSINE A ON HL-60 CELLS AND ITS REGULATION ON TELOMERASE ACTIVITY

SHEN Jia ying,YANG Bo, Rizhao People's Hospital (Rizhao,276800) [  
Objective:To investigate the influence of rebescensine A on HL 60 cells and its regulation on telomerase activity and bcl 2 expression.Methods:MTT assay was used to observe the inhibition of HL 60 cells and flow cytometry(FCM) was used to examine cell apoptosis and bcl 2 expression,while telomerase activity was detected by TRAP.Results:Cell growth was considerably inhibited by rebescensine A and apoptosis appeared concurrently,along with these variation the telomerase activity and bcl 2 expression were reduced significantly.Conclusion:Rebescensine A can suppress the proliferation and induce apoptosis on HL 60 cells,it may be related to the reduction of telomerase activity and bcl 2 expression,especially bcl 2 may play an important role in the mechanism.
【CateGory Index】: R733.71
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