THE CHARACTER AND SIGNIFICANCE OF IMMUNOPHENOTYPE IN 71 CASES OF ACUTE LEUKEMIA

Zhang Hong, Liang Jianying, Li Jun, et al. Department of Hematology,The Second Affiliated Hospital of Suzhou University (Suzhou, 215004)  

Objective: To investigate the immunophenotype of acute leukemia(AL) and its clinical significance. Methods: Immunophenotype were examined by flow cytometry in 71 cases of AL. Results: Most patients mainly expressed lineage antigen related to their origin, but some patients had bilineage antigen expression or no specific CD antigen expression or mixed lineage. Expression of CD34 and HLA- DR were in 56.3 % and 61.9 % of AL patients, respectively. There was no HLA- DA expression in M3 patients. Complete remission(CR) rate in myeloid antigen positive ALL(60.0 %) was slightly lower than those in myeloid antigen negative ALL(89.5 %),but there was no statistic significant(P0.05). CR rate in CD+34 ALL was almost the same as that in CD 34 ALL. CR rate in CD+34 AML was significantly lower than those in CD- 34 AML(58.3 % vs 88.9 %,P0.05). Conclusion: The immunophenotype analysis of AL combined with morphology may help in AL diagnosis and expression of some specific lineage antigen had prognostic value.

【Key Words】： Acute leukemia Immunophenotype Flow cytometry Prognosis
【CateGory Index】： R733.71;R730.45

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