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《JOURNAL OF LEUKEMIA》 1999-03
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ANALYSIS OF TELOMERASE ACTIVITY IN LEUKEMICCELLS AND NORMAL LEUCOCYTES

Zheng Xiaofei,Li Xinquan,Wang Shengqi, et al .WT5BXInstitute of Radiation Medicine,Academy of Military Medical Sciences(Beijing,100850)  
Objective To investigate the association of the telomerase activity with leukemic cells and normal leucocytes. Methods The reform TRAP was performed to analysis bone marrow samples of leukemic patients and normal human white blood cells. Results The strong telomerase activity was found in leukemic patients with high cells load and is relative to abnormal chromosome karyotypes and clinical prognostic relveance.The telomerase activity were undetectable or at lower level in normal human white blood cells. Conclusion The experssion of telomerase in leukemia makes these disorders interesting targets for future diagnosis and antitelomerase therapy.
【Key Words】: LeukemiaTelomerase
【Fund】: 中国博士后科学基金
【CateGory Index】: R730.231.3,R733.71
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