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《China Journal of Traditional Chinese Medicine and Pharmacy》 1998-02
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A Screening STudy on the effects of activity ingredients in hinese Herbs on Anti-multidrug Resistance Cell Line in Vitro

Hu Kaiwen (Affiliated Dongzhimen Hospital of Beijing University of Chinese Medicine and pharmacology, Beijing)  
The authors investigated the cytotoxicity of ingredients of Chinese herbs, such as osides, rhiem an-thraquinone and alkaloids, and studied the reversal activity of drug-resistance by these ingredients on mul-tidrug-resistance cell lines-MCF-7/ADR and HL60/ADR with different mechanisms. The results showed that in vitro, using the routine dose, osides had no cytotoxicity on drug-resistant or drug-sensitive cell lines, and had no effect on the drug - resistance; rhiem anthraquinone had more strong cytotoxicity on drug - resistant cell lines than on drug sensitive cell lines, but had no reversal activity of drug-resistance. Whereas, alkaloids had light cytotoxicity on drug-resistant cell lines than steroidal alkaloids PM1 and PM2 could significantly reverse multidrug-resistance of MCF-7/ADR and HL60/ADR cell lines, and markedly intensify effect of anti-cancer agents.
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【CateGory Index】： R273
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