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《China Journal of Traditional Chinese Medicine and Pharmacy》 1999-06
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Experimental Study on Effect of Zhiling Decoction in Treating Model of Senile Rat with Demantia

Zuo Fengying , et al ( Weifang Medical College , Shandong)  
To explore the pharmacodynamic effects of Zhiling Decoction (ZLD) in modei of senile rat with de-mentia. Using 22 months SD rat, decoction model established by destroying basai ganglia. Using ZLD treated the decoction modei then observed the function of learning and memory in decoction models; ob-served the serum enzyme, M receptor of brain tissue and ultreastructure change of brain tissue in decoction models. ZLD could improve the function of learning and memory in decoction models, could de-crease the level of serum choline activity (CHE) , decrease the monoamine oxidize (MAO) significant-ly; increased the Ievel of serum SOD, increased the number and affinity of M receptor in brain. The ul-trastructure showed more improvement than the non - treatment group. ZLD could increase numbers of M receptor in the brain, clear free radicals, protect biomembrance, inhibit the formation of lipofuscin the brain, promote synthesis of protein and energy metabolism in the nerve cells, promote blood - supply in the brain.
【Fund】: 山东省中医管理局基金
【CateGory Index】: R285
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